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Product Details
17002-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TBC1D23 Fusion Protein Ag10697 (1-320 aa encoded by BC010221)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to TBC1D23.
Immunogen sequence: MLQNPSEFA QSVKSLLEAQ KQSIESGSIA GGEHLCFMGS GREEEDMYMN MVLAHFLQKN KEYVSIASGG FMALQQHLAD INVDGPENGY GHWIASTSGS RSSINSVDGE SPNGSSDRGM KSLVNKMTVA LKTKSVNVRE KVISFIENTS TPVDRHVSSS DRVGKPYRGV KPVFSIGDEE EYDTDEIDSS SMSDDDRKEV VNIQTWINKP DVKHHFPCKE VKESGHMFPS HLLVTATHMY CLREIVSRKG LAYIQSRQAL NSVVKITSKK KHPELITFKY GNSSASGIEI LAIERYLIPN AGDATKAIKQ QIMKVLDALE S (1-320 aa encoded by BC010221)
Target Information
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HCV non-structural protein 4A-transactivated protein 1; HCV nonstructural protein 4A-transactivated protein 1; TBC1 domain family member 23; TBC1 domain family, member 23
Gene Aliases: 4930451A13Rik; AU015720; AU043671; AU043778; D030022P07Rik; NS4ATP1; RGD1307925; TBC1D23; W51689
UniProt ID: (Human) Q9NUY8, (Mouse) Q8K0F1
Entrez Gene ID: (Human) 55773, (Mouse) 67581, (Rat) 304019
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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