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Invitrogen
TBC1D23 Polyclonal Antibody
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Product Details
PA5-58274
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TBC1D23. Recombinant protein control fragment (Product #RP-96258).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2648264
Product Specific Information
Immunogen sequence: HLSTAFHLDS DLMLQNPSEF AQSVKSLLEA QKQSIESGSI AGGEHLCFMG SGREEEDMYM NMVLAHFLQK NKEYVSIASG GFMALQQHLA DINVDGPENG Y
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.
Target Information
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HCV non-structural protein 4A-transactivated protein 1; HCV nonstructural protein 4A-transactivated protein 1; TBC1 domain family member 23; TBC1 domain family, member 23
Gene Aliases: NS4ATP1; TBC1D23
UniProt ID: (Human) Q9NUY8
Entrez Gene ID: (Human) 55773
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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