Proteintech

TBC1D5 Polyclonal Antibody

TBC1D5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

TBC1D5 Antibody (17078-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using (Product # 17078-1-AP) (TBC1D5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

TBC1D5 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17078-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TBC1D5 Fusion Protein Ag10991 (445-795 aa encoded by BC013145)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TNAKGAPLN INKVSNSLIN FGRKLISPAM APGSAGGPVP GGNSSSSSSV VIPTRTSAEA PSHHLQQQQQ QQRLMKSESM PVQLNKGLSS KNISSSPSVE SLPGGREFTG SPPSSATKKD SFFSNISRSR SHSKTMGRKE SEEELEAQIS FLQGQLNDLD AMCKYCAKVM DTHLVNIQDV ILQENLEKED QILVSLAGLK QIKDILKGSL RFNQSQLEAE ENEQITIADN HYCSSGQGQG RGQGQSVQMS GAIKQASSET PGCTDRGNSD DFILISKDDD GSSARGSFSG QAQPLRTLRS TSGKSQAPVC SPLVFSDPLM GPASASSSNP SSSPDDDSSK DSGFTIVSPL DI (445-795 aa encoded by BC013145)

Target Information

TBC1 domain family member 5 (TBC1D5) may act as a GTPase-activating protein for Rab family protein(s).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

TBK1 Facilitates GLUT1-Dependent Glucose Consumption by suppressing mTORC1 Signaling in Colorectal Cancer Progression.

International journal of biological sciences

Zhou D,Yao Y,Zong L,Zhou G,Feng M,Chen J,Liu G,Chen G,Sun K,Yao H,Liu Y,Shi X,Zhang W,Shi B,Tai Q,Wu G,Sun L,Hu W,Zhu X,He S

Thu Jun 02 00:00:00 UTC 2022

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

EMBO reports

Kannangara AR,Poole DM,McEwan CM,Youngs JC,Weerasekara VK,Thornock AM,Lazaro MT,Balasooriya ER,Oh LM,Soderblom EJ,Lee JJ,Simmons DL,Andersen JL

Tue Oct 05 00:00:00 UTC 2021

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.

Science advances

Chen KE,Guo Q,Hill TA,Cui Y,Kendall AK,Yang Z,Hall RJ,Healy MD,Sacharz J,Norwood SJ,Fonseka S,Xie B,Reid RC,Leneva N,Parton RG,Ghai R,Stroud DA,Fairlie DP,Suga H,Jackson LP,Teasdale RD,Passioura T,Collins BM

Fri Dec 03 00:00:00 UTC 2021

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.

Science advances

Fri Dec 03 00:00:00 UTC 2021

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling.

The Journal of cell biology

Kvainickas A,Nägele H,Qi W,Dokládal L,Jimenez-Orgaz A,Stehl L,Gangurde D,Zhao Q,Hu Z,Dengjel J,De Virgilio C,Baumeister R,Steinberg F

Mon Sep 02 00:00:00 UTC 2019

Control of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy.

The EMBO journal

Jimenez-Orgaz A,Kvainickas A,Nägele H,Denner J,Eimer S,Dengjel J,Steinberg F

Wed Jan 17 00:00:00 UTC 2018

Control of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy.

The EMBO journal

Jimenez-Orgaz A,Kvainickas A,Nägele H,Denner J,Eimer S,Dengjel J,Steinberg F

Wed Jan 17 00:00:00 UTC 2018

TBC1D5 controls the GTPase cycle of Rab7b.

Journal of cell science

Borg Distefano M,Hofstad Haugen L,Wang Y,Perdreau-Dahl H,Kjos I,Jia D,Morth JP,Neefjes J,Bakke O,Progida C

Mon Sep 03 00:00:00 UTC 2018

TBC1D5 controls the GTPase cycle of Rab7b.

Journal of cell science

Borg Distefano M,Hofstad Haugen L,Wang Y,Perdreau-Dahl H,Kjos I,Jia D,Morth JP,Neefjes J,Bakke O,Progida C

Mon Sep 03 00:00:00 UTC 2018

TBC1D5 controls the GTPase cycle of Rab7b.

Journal of cell science

Borg Distefano M,Hofstad Haugen L,Wang Y,Perdreau-Dahl H,Kjos I,Jia D,Morth JP,Neefjes J,Bakke O,Progida C

Mon Sep 03 00:00:00 UTC 2018

TBC1D5 controls the GTPase cycle of Rab7b.

Journal of cell science

Borg Distefano M,Hofstad Haugen L,Wang Y,Perdreau-Dahl H,Kjos I,Jia D,Morth JP,Neefjes J,Bakke O,Progida C

Mon Sep 03 00:00:00 UTC 2018

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.

Molecular biology of the cell

Gomez TS,Gorman JA,de Narvajas AA,Koenig AO,Billadeau DD

Wed Aug 01 00:00:00 UTC 2012

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.

Molecular biology of the cell

Gomez TS,Gorman JA,de Narvajas AA,Koenig AO,Billadeau DD

Wed Aug 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: TBC1 domain family member 5; TBC1 domain family, member 5

View more View less

Gene Aliases: 1600014N05Rik; KIAA0210; TBC1D5

View more View less

UniProt ID: (Human) Q92609, (Mouse) Q80XQ2

View more View less

Entrez Gene ID: (Human) 9779, (Mouse) 72238

View more View less

Function(s)

GTPase activator activity protein binding Rab GTPase binding AP-2 adaptor complex binding

Process(es)

positive regulation of receptor internalization transport autophagy positive regulation of autophagy protein transport retrograde transport, endosome to Golgi response to starvation mitophagy in response to mitochondrial depolarization intracellular protein transport regulation of vesicle fusion activation of GTPase activity regulation of cilium assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

TBC1D5 Polyclonal Antibody

TBC1D5 Antibody (17078-1-AP) in IHC (P)

Product Details

17078-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!