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Invitrogen
TBL1X Polyclonal Antibody
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FIGURE: 1 / 1
TBL1X Antibody (PA5-90222) in WB
Western blot analysis of TBL1X in extracts of various cell lines. Samples were incubated with TBL1X Polyclonal antibody (Product # PA5-90222) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-90222
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TBL1X (NP_0056381)
Conjugate
Form
Liquid
Concentration
0.67 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805969
Product Specific Information
Immunogen sequence: LISILQKGLQ YVEAEISINE DGTVFDGRPI ESLSLIDAVM PDVVQTRQQA FREKLAQQQA SAAAAAAAAT AAATAATTTS AGVSHQNPSK NREATVNGEE N; Positive Samples: BxPC-3, HeLa, mouse brain, mouse lung; Cellular Location: Nucleus
Target Information
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: F-box-like/WD repeat-containing protein TBL1X; SMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked
Gene Aliases: 5330429M20; EBI; RGD1563868; SMAP55; TBL1; TBL1X
UniProt ID: (Human) O60907, (Mouse) Q9QXE7
Entrez Gene ID: (Human) 6907, (Mouse) 21372, (Rat) 302711
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
proteolysis
sensory perception of sound
histone deacetylation
proteasome-mediated ubiquitin-dependent protein catabolic process
response to estrogen
fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to steroid hormone
canonical Wnt signaling pathway
biological_process
cellular lipid metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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