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Invitrogen
TBLR1 Polyclonal Antibody
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Product Details
PA5-89235
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 120-170 of human TBL1XR1 (NP_0789412)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805436
Product Specific Information
Immunogen sequence: QQGSAKNGEN TANGEENGAH TIANNHTDMM EVDGDVEIPP NKAVVLRGHE S
Positive Samples: Jurkat, HepG2, NCI-H460, THP-1, Mouse brain, Mouse spleen, Mouse thymus; Cellular Location: Nucleus
Target Information
Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thought to mediate repression, at least in part, by their ability to recruit histone deacetylases to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes, and its presence is thought to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Although TBLR1 is thought to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: F-box-like/WD repeat protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; FLJ12894; nuclear receptor co-repressor/HDAC3 complex subunit; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1
Gene Aliases: 8030499H02Rik; A630076E03Rik; AW539987; C21; C230089I12Rik; DC42; IRA1; MRD41; TBL1XR1; TBLR1
UniProt ID: (Human) Q9BZK7, (Mouse) Q8BHJ5
Entrez Gene ID: (Human) 79718, (Mouse) 81004
negative regulation of transcription from RNA polymerase II promoter
response to dietary excess
transcription, DNA-templated
lipid catabolic process
histone deacetylation
regulation of cAMP metabolic process
multicellular organism growth
proteasome-mediated ubiquitin-dependent protein catabolic process
cellular lipid metabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
white fat cell differentiation
canonical Wnt signaling pathway
fat pad development
regulation of triglyceride metabolic process
regulation of transcription, DNA-templated
regulation of gene expression
chromatin modification
negative regulation of transcription, DNA-templated
adipose tissue development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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