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Invitrogen
TBR1 Polyclonal Antibody
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FIGURE: 1 / 2
TBR1 Antibody (PA5-114784) in ICC/IF
Immunocytochemistry analysis of TBR1 in A549 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114784). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Product Details
PA5-114784
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TBR1(Accession Q16650), corresponding to amino acid residues P38-D88.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2899420
Product Specific Information
Antibody detects endogenous levels of total TBR1.
Target Information
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: T-box brain gene 1; T-box brain protein 1; T-box, brain, 1; T-box, brain, 1-like; T-brain-1; TBR-1; TES-56
Gene Aliases: TBR-1; TBR1; TES-56
UniProt ID: (Human) Q16650, (Mouse) Q64336
Entrez Gene ID: (Human) 10716, (Mouse) 21375, (Rat) 680427
conditioned taste aversion
transcription, DNA-templated
regulation of transcription, DNA-templated
specification of organ identity
regulation of gene expression
regulation of neuron projection development
amygdala development
commitment of neuronal cell to specific neuron type in forebrain
neuron differentiation
hindbrain development
positive regulation of transcription from RNA polymerase II promoter
regulation of axon guidance
brain development
axon guidance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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