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          • Primary Antibodies ›
          • TBX18 Antibodies

          Proteintech

          TBX18 Polyclonal Antibody

          2 References
          View all (9) TBX18 antibodies

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          Cite TBX18 Polyclonal Antibody

          • Antibody Testing Data (10)
          TBX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          TBX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          FIGURE: 1 / 10

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          TBX18 Antibody (23237-1-AP) in IHC (P)

          Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 23237-1-AP ( TBX18 Antibody) at dilution of 1:50 (under 40x lens). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          TBX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TBX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TBX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TBX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TBX18 Antibody in Western Blot (WB)
          TBX18 Antibody in Western Blot (WB)
          TBX18 Antibody in Western Blot (WB)
          TBX18 Antibody in Western Blot (WB)
          TBX18 Antibody in Western Blot (WB)
          TBX18 Antibody in Western Blot (WB)

          Product Details

          23237-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          View 1 publication 1 publication

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -

          Immunocytochemistry (ICC/IF)

          -
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          TBX18 Fusion Protein Ag19258 (350-532 aa encoded by BC157841)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.35 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          This antibody specifically reacts with the 65 kDa TBX18 protein.

          Immunogen sequence: PSLRTLTFE DIPGIPKQGN ASSSTLLQGT GNGVPATHPH LLSGSSCSSP AFHLGPNTSQ LCSLAPADYS ACARSGLTLN RYSTSLAETY NRLTNQAGET FAPPRTPSYV GVSSSTSVNM SMGGTDGDTF SCPQTSLSMQ ISGMSPQLQY IMPSPSSNAF ATNQTHQGSY NTFRLHSPCA LYGY (350-532 aa encoded by B C157841)

          Target Information

          The T-box (Tbx) motif is present in a family of genes whose structural features and expression patterns support their involvement in developmental gene regulation. The Tbx gene family are largely conserved throughout metazoan evolution, and these genes code for putative transcription factors that share a uniquely defining DNA-binding domain. Tbx genes are a family of developmental regulators with more than 20 members recently identified in invertebrates and vertebrates. Mutations in Tbx genes are associated with the onset of several human diseases. Our understanding of functional mechanisms of Tbx products has come mainly from the prototypical T/Brachyury, which is a transcription activator. The Tbx genes constitute a family of transcriptional regulatory genes that are implicated in a variety of developmental processes ranging from the formation of germ layers to the organizational patterning of the central nervous system.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: T-box protein 14; T-box protein 15; T-box protein 18; T-box transcription factor TBX18; TBX14; TBX15

          View more View less

          Gene Aliases: 2810012F10Rik; 2810404D13Rik; CAKUT2; TBX18

          View more View less

          UniProt ID: (Human) O95935, (Mouse) Q9EPZ6

          View more View less

          Entrez Gene ID: (Human) 9096, (Rat) 315870, (Mouse) 76365

          View more View less

          Function(s)
          transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding protein binding protein homodimerization activity protein heterodimerization activity RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding molecular_function DNA binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter somitogenesis positive regulation of mesenchymal cell proliferation sinoatrial node development transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter sensory perception of sound biological_process anterior/posterior axis specification morphogenesis of embryonic epithelium positive regulation of cell-cell adhesion cell differentiation anatomical structure formation involved in morphogenesis positive regulation of epithelial cell proliferation smooth muscle cell differentiation negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation ureter development cochlea morphogenesis positive regulation of mesenchymal cell proliferation involved in ureter development multicellular organism development renal system development
          It has to be done as per old AB suggested Products section.
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