Invitrogen

TBX2/3 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-116010

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TBX3(Accession O15119), corresponding to amino acid residues A283-N333.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2900644

Product Specific Information

Antibody detects endogenous levels of total TBX 2/3.

Target Information

TBX2 (T-Box Transcription Factor 2) is a Protein Coding gene. Diseases associated with TBX2 include Vertebral Anomalies And Variable Endocrine And T-Cell Dysfunction and Ulnar-Mammary Syndrome. Among its related pathways are Heart Development and Inhibition of Ribosome Biogenesis by p14(ARF). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is TBX3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bladder cancer related protein XHL; T-box 3 (ulnar mammary syndrome); T-box protein 2; T-box protein 3; T-box transcription factor TBX2; T-box transcription factor TBX3; TBX2; TBX3; TBX3/2

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Gene Aliases: D5Ertd189e; TBX2; TBX3; TBX3-ISO; UMS; XHL

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UniProt ID: (Human) Q13207, (Human) O15119, (Mouse) Q60707, (Mouse) P70324, (Rat) Q7TST9

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Entrez Gene ID: (Human) 6909, (Human) 6926, (Mouse) 21385, (Rat) 303398, (Mouse) 21386, (Rat) 353305

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding protein binding sequence-specific DNA binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding transcription factor activity, sequence-specific DNA binding molecular_function
Process(es)
negative regulation of transcription from RNA polymerase II promoter heart looping outflow tract septum morphogenesis outflow tract morphogenesis endocardial cushion morphogenesis regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation transcription, DNA-templated Notch signaling pathway muscle cell fate determination cell aging regulation of heart contraction positive regulation of cell proliferation embryonic heart tube development aorta morphogenesis atrioventricular canal development embryonic digit morphogenesis negative regulation of transcription, DNA-templated embryonic camera-type eye morphogenesis cardiac muscle tissue development palate development positive regulation of cardiac muscle cell proliferation pharynx development developmental growth involved in morphogenesis mammary placode formation cellular senescence negative regulation of heart looping negative regulation of cardiac chamber formation skeletal system development blood vessel development in utero embryonic development atrioventricular bundle cell differentiation regulation of transcription from RNA polymerase II promoter anterior/posterior axis specification, embryo organ morphogenesis specification of organ position stem cell population maintenance limbic system development male genitalia development female genitalia development negative regulation of epithelial cell differentiation mammary gland development luteinizing hormone secretion embryonic forelimb morphogenesis embryonic hindlimb morphogenesis forelimb morphogenesis negative regulation of apoptotic process negative regulation of myoblast differentiation positive regulation of cell cycle positive regulation of transcription, DNA-templated follicle-stimulating hormone secretion mesoderm morphogenesis ventricular septum morphogenesis branching involved in mammary gland duct morphogenesis cardiac muscle cell fate commitment sinoatrial node cell development positive regulation of stem cell proliferation heart morphogenesis regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development limb morphogenesis regulation of cell proliferation cardiac muscle cell differentiation
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