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This antibody is predicted to react with chicken, rat and Xenopus based on sequence homology.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity.
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Protein Aliases: T-box protein 4; T-box transcription factor TBX4
Gene Aliases: 3930401C23; ICPPS; SPS; TBX4
UniProt ID: (Human) P57082, (Mouse) P70325
Entrez Gene ID: (Human) 9496, (Mouse) 21387
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