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Abnova
TBX5 Polyclonal Antibody, MaxPab™
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Product Details
H00006910-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TBX5 (AAH27942.1, 1 a.a. approximately 518 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Tissue lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MADADEGFGL AHTPLEPDAK DLPCDSKPES ALGAPSKSPS SPQAAFTQQG MEGIKVFLHE RELWLKFHEV GTEMIITKAG RRMFPSYKVK VTGLNPKTKY ILLMDIVPAD DHRYKFADNK WSVTGKAEPA MPGRLYVHPD SPATGAHWMR QLVSFQKLKL TNNHLDPFGH IILNSMHKYQ PRLHIVKADE NNGFGSKNTA FCTHVFPETA FIAVTSYQNH KITQLKIENN PFAKGFRGSD DMELHRMSRM QSKEYPVVPR STVRQKVASN HSPFSSESRA LSTSSNLGSQ YQCENGVSGP SQDLLPPPNP YPLPQEHSQI YHCTKRKEEE CSTTDHPYKK PYMETSPSEE DSFYRSSYPQ QQGLGASYRT ESAQRQACMY ASSAPPSEPV PSLEDISCNT WPSMPSYSSC TVTTVQPMDR LPYQHFSAHF TSGPLVPRLA GMANHGSPQL GEGMFQHQTS VAHQPVVRQC GPQTGLQSPG TLQPPEFLYS HGVPRTLSPH QYHSVHGVGM VPEWSDNS
Target Information
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: T-box protein 5; T-box transcription factor TBX5
Gene Aliases: HOS; TBX5
UniProt ID: (Human) Q99593, (Mouse) P70326
Entrez Gene ID: (Human) 6910, (Mouse) 21388
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
sequence-specific DNA binding
morphogenesis of an epithelium
bundle of His development
atrioventricular valve morphogenesis
endocardial cushion development
cardiac left ventricle formation
ventricular septum development
transcription initiation from RNA polymerase II promoter
cell-cell signaling
pattern specification process
heart development
negative regulation of cell proliferation
negative regulation of epithelial to mesenchymal transition
lung development
embryonic limb morphogenesis
negative regulation of cell migration
embryonic forelimb morphogenesis
forelimb morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cardioblast differentiation
cardiac muscle cell differentiation
pericardium development
negative regulation of cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
transdifferentiation
atrial septum morphogenesis
cell migration involved in coronary vasculogenesis
positive regulation of secondary heart field cardioblast proliferation
regulation of execution phase of apoptosis
ventricular cardiac muscle tissue development
atrial septum development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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