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Product Details
PA5-118797
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TBXA2R(Accession P21731), corresponding to amino acid residues V263-R313.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2903297
Product Specific Information
Antibody detects endogenous levels of total TAS2R.
Target Information
The thromboxane A2 receptor (TBXA2R) is a member of the Prostanoid Receptor subfamily. TBXA2R performs an essential role in hemostasis by interacting with thromboxane A2 to induce platelet aggregation. Thromboxane A2 has been implicated in myocardial infarct, stroke, and asthma. Additionally, thromboxane-prostanoid receptors have been implicated in the pathogenesis of cardiovascular diseases. Changes in TBXA2R function have also been linked to a hereditary bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Prostanoid TP receptor; Thromboxane A2 receptor; thromboxane prostanoid; Thromboxane receptor; TXA2 receptor; TXA2-R; TXR2
Gene Aliases: BDPLT13; TBXA2R; TP; TXA2-R
UniProt ID: (Human) P21731, (Mouse) P30987, (Rat) P34978
Entrez Gene ID: (Human) 6915, (Mouse) 21390, (Rat) 24816
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of vasoconstriction
second-messenger-mediated signaling
response to lipopolysaccharide
positive regulation of angiogenesis
positive regulation of blood pressure
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
response to nutrient
thromboxane A2 signaling pathway
response to drug
positive regulation of GTPase activity
water homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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