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Proteintech
TCF12 Monoclonal Antibody (1B8D4), CoraLite® Plus 488
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FIGURE: 1 / 1
TCF12 Antibody (CL488-67523) in Flow
1X10^6 HepG2 cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human TCF12 (CL488-67523, Clone:1B8D4) (red), or 0.4 µg Mouse IgG2a Isotype Control (CL488-66360-2, Clone: K11A1B2A2) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL488-67523
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1B8D4
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SNPSTPVGSP SPLTGTSQWP RPGGQAPSSP SYENSLHSLK NRVEQQLHEH LQDAMSFLKD VCEQSRMEDR LDRLDDAIHV LRNHAVGPST SLPAGHSDIH SLLGPSHNAP IGSLNSNYGG SSLVASSRSA SMVGTHREDS VSLNGNHSVL SSTVTTSSTD LNHKTQENYR GGLQSQSGTV VTTEIKTENK EKDENLHEPP SSDDMKSDDE SSQKDIKVSS RGRTSSTNED EDLNPEQKIE REKERRMANN ARERLRVRDI NEAFKELGRM CQLHLKSEKP QTKLLILHQA VAVILSLEQQ VRERNLNPKA ACLKRREEEK VSAVSAEPPT TLPGTHPGLS ETTNPMGHM
Target Information
TCF12, also known as HTF4, is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. TCF12 is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. TCF12, in combination with E2A, is required to block thymocyte proliferation prior to pre-TCR expression and is critical for proper T cell differentiation. Recent reports have shown that TCF12 is also a critical factor required for the development of invariant natural killer T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHb20; Class A helix-loop-helix transcription factor ME1; Class B basic helix-loop-helix protein 20; DNA-binding protein HTF4; E-box-binding protein; helix-loop-helix transcription factor 4; Salivary-specific cAMP response element-binding protein alpha; SCBP alpha; SCBP-alpha; TCF-12; Transcription factor 12; Transcription factor HTF-4
Gene Aliases: A130037E08Rik; ALF1; BHLHB20; CRS3; HEB; HEBAlt; HsT17266; HTF-4; HTF4; ME1; Meb; REB; SCBPA; TCF-12; TCF12
UniProt ID: (Human) Q99081, (Mouse) Q61286, (Rat) P51514
Entrez Gene ID: (Human) 6938, (Mouse) 21406, (Rat) 25720
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
enhancer binding
cAMP response element binding
protein homodimerization activity
bHLH transcription factor binding
transcription regulatory region DNA binding
SMAD binding
protein heterodimerization activity
E-box binding
HMG box domain binding
DNA binding
protein dimerization activity
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
nervous system development
positive regulation of gene expression
cell differentiation
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
immune response
muscle organ development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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