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Huabio
TCF21 Polyclonal Antibody
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FIGURE: 1 / 1
TCF21 Antibody (HA500188) in WB
Western blot analysis of TCF21 on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (HA500188, 1:500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:5,000 dilution was used for 1 hour at room temperature. Positive control: Lane 1: HeLa cell lysate Lane 2: 293T cell lysate Lane 3: K562 cell lysate Lane 4: Human lung tissue lysate.
Product Details
HA500188
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human TCF21 aa 125-175.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The basic helix-loop-helix transcription factor TCF21/Pod1 (also called capsulin or epicardin) is involved in kidney, lung and spleen organogenesis. It is also essential for normal development of the testes and ovaries. TCF21/Pod1 is involved in the transcriptional repression of steroidogenic factor 1 (Sf1/Nr5a1/Ad4BP), an orphan nuclear receptor that regulates the expression of multiple genes (including Scc) that mediate sexual differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHa23; Capsulin; Class A basic helix-loop-helix protein 23; Epicardin; Pod-1; Podocyte-expressed 1; TCF-21; Transcription factor 21
Gene Aliases: BHLHA23; POD1; TCF21
UniProt ID: (Human) O43680
Entrez Gene ID: (Human) 6943
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
histone deacetylase binding
bHLH transcription factor binding
protein dimerization activity
androgen receptor binding
E-box binding
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
branching involved in ureteric bud morphogenesis
morphogenesis of a branching structure
kidney development
vasculature development
transcription from RNA polymerase II promoter
sex determination
branchiomeric skeletal muscle development
epithelial cell differentiation
glomerulus development
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
spleen development
embryonic digestive tract morphogenesis
reproductive structure development
gland development
Sertoli cell differentiation
palate development
lung morphogenesis
lung vasculature development
bronchiole development
diaphragm development
respiratory system development
negative regulation of androgen receptor signaling pathway
metanephric mesenchymal cell differentiation
metanephric glomerular capillary formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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