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Invitrogen
TCF21 Polyclonal Antibody
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Product Details
PA5-144734
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 125-179. Recombinant protein control fragment (Product #RP-109733).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3092213
Product Specific Information
Immunogen sequence: SSYIAHLRQI LANDKYENGY IHPVNLTWPF MVAGKPESDL KEVVTASRLC GTTAS
Antigen sequence identity: Mouse 96%; Rat 100%
Target Information
The basic helix-loop-helix transcription factor TCF21/Pod1 (also called capsulin or epicardin) is involved in kidney, lung and spleen organogenesis. It is also essential for normal development of the testes and ovaries. TCF21/Pod1 is involved in the transcriptional repression of steroidogenic factor 1 (Sf1/Nr5a1/Ad4BP), an orphan nuclear receptor that regulates the expression of multiple genes (including Scc) that mediate sexual differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHa23; Capsulin; Class A basic helix-loop-helix protein 23; Epicardin; Pod-1; Podocyte-expressed 1; TCF-21; Transcription factor 21
Gene Aliases: BHLHA23; POD1; TCF21
UniProt ID: (Human) O43680
Entrez Gene ID: (Human) 6943
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
histone deacetylase binding
bHLH transcription factor binding
protein dimerization activity
androgen receptor binding
E-box binding
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
branching involved in ureteric bud morphogenesis
morphogenesis of a branching structure
kidney development
vasculature development
transcription from RNA polymerase II promoter
sex determination
branchiomeric skeletal muscle development
epithelial cell differentiation
glomerulus development
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
spleen development
embryonic digestive tract morphogenesis
reproductive structure development
gland development
Sertoli cell differentiation
palate development
lung morphogenesis
lung vasculature development
bronchiole development
diaphragm development
respiratory system development
negative regulation of androgen receptor signaling pathway
metanephric mesenchymal cell differentiation
metanephric glomerular capillary formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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