Invitrogen

TCF3 Polyclonal Antibody

View all (23) TCF3 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-86463

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to amino acids 570-620 of Human TCF-3.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803241

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

TCF3 (E2A) is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLHb21; Class B basic helix-loop-helix protein 21; helix-loop-helix protein HE47; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; MGC129647; MGC129648; negative vitamin D response element-binding protein; NOL1-TCF3 fusion; Pancreas specific transcription factor 1c; TCF-3; Transcription factor 3; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); transcription factor 3 variant 3; Transcription factor A1; Transcription factor E2-alpha; transcription factor E2a; Transcription factor ITF-1; Transcription regulator Pan; VDR interacting repressor; vitamin D receptor-interacting repressor

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Gene Aliases: A1; AA408400; AGM8; ALF2; AW209082; BHLHB21; E12; E12/E47; E2A; E47; ITF1; ME2; Pan; Pan1; Pan2; Ptf1c; TCF-3; TCF3; Tcfe2a; VDIR

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UniProt ID: (Human) P15923, (Mouse) P15806, (Rat) P21677

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Entrez Gene ID: (Human) 6929, (Mouse) 21423, (Rat) 171046

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding transcription factor binding mitogen-activated protein kinase kinase kinase binding enhancer binding protein homodimerization activity bHLH transcription factor binding protein heterodimerization activity repressing transcription factor binding vitamin D response element binding E-box binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding chromatin binding PDZ domain binding sequence-specific DNA binding transcription regulatory region DNA binding protein dimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter natural killer cell differentiation B cell lineage commitment transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter gastrulation nervous system development positive regulation of gene expression lymphocyte differentiation cell differentiation positive regulation of B cell proliferation response to lipopolysaccharide T cell differentiation in thymus immunoglobulin V(D)J recombination response to drug histone H3 acetylation histone H4 acetylation positive regulation of neuron differentiation positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell development Peyer's patch development protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity regulation of G1/S transition of mitotic cell cycle B cell differentiation positive regulation of muscle cell differentiation
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