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Product Details
PA5-106756
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TCF4(Accession P15884), corresponding to amino acid residues K596-P646.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2854424
Product Specific Information
Antibody detects endogenous levels of total TCF4/12.
Target Information
T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group(HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to beta-catenin in a cooperative manner. This TCF-4/ beta-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHb19; bHLHb20; Class A helix-loop-helix transcription factor ME1; Class A helix-loop-helix transcription factor ME2; Class B basic helix-loop-helix protein 19; Class B basic helix-loop-helix protein 20; DNA-binding protein HTF4; E-box-binding protein; helix-loop-helix transcription factor 4; Immunoglobulin transcription factor 2; immunoglobulin transcription factor-2; ITF-2; MITF-2; R8f DNA-binding protein; RITF-2; Salivary-specific cAMP response element-binding protein alpha; SCBP alpha; SCBP-alpha; SEF-2; SL3-3 enhancer factor 2; TCF-12; TCF-4; Transcription factor 12; Transcription factor 4; Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2); transcription factor 4, isoform C; transcription factor 4, isoform D; transcription factor 4, isoform E; transcription factor 4, isoform L; transcription factor 4, isoform M; transcription factor 4, isoform R; Transcription factor HTF-4
Gene Aliases: 5730422P05Rik; A130037E08Rik; ALF1; ASP-I2; BHLHB19; BHLHB20; CRS3; E2-2; E2.2; FECD3; HEB; HEBAlt; HsT17266; HTF-4; HTF4; ITF-2; ITF-2b; ITF2; ME1; ME2; Meb; MITF-2A; MITF-2B; PTHS; REB; SCBPA; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-12; TCF-4; TCF12; TCF4; TFE
UniProt ID: (Human) Q99081, (Human) P15884, (Mouse) Q61286, (Rat) P51514, (Mouse) Q60722, (Rat) Q62655
Entrez Gene ID: (Human) 6938, (Human) 6925, (Mouse) 21406, (Rat) 25720, (Mouse) 21413, (Rat) 84382
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
enhancer binding
cAMP response element binding
protein homodimerization activity
bHLH transcription factor binding
transcription regulatory region DNA binding
SMAD binding
protein heterodimerization activity
E-box binding
HMG box domain binding
transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting
transcription factor activity, TFIIB-class binding
TFIIB-class transcription factor binding
DNA binding
protein C-terminus binding
identical protein binding
protein dimerization activity
chromatin binding
double-stranded DNA binding
transcription corepressor activity
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
nervous system development
positive regulation of gene expression
cell differentiation
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
DNA-templated transcription, initiation
transcription initiation from RNA polymerase II promoter
protein-DNA complex assembly
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
immune response
muscle organ development
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