Proteintech

TCF7L1 Polyclonal Antibody

TCF7L1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TCF7L1 Antibody (14519-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer using 14519-1-AP (TCF7L1 antibody) at dilution of 1:100 (under 40x lens).

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Product Details

14519-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TCF7L1 Fusion Protein Ag5983 (238-587 aa encoded by BC058894)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GAVGQIPHP LGWLVPQQGQ PMYSLPPGGF RHPYPALAMN ASMSSLVSSR FSPHMVAPAH PGLPTSGIPH PAIVSPIVKQ EPAPPSLSPA VSVKSPVTVK KEEEKKPHVK KPLNAFMLYM KEMRAKVVAE CTLKESAAIN QILGRKWHNL SREEQAKYYE LARKERQLHS QLYPTWSARD NYGKKKKRKR EKQLSQTQSQ QQVQEAEGAL ASKSKKPCVQ YLPPEKPCDS PASSHGSMLD SPATPSAALA SPAAPAATHS EQAQPLSLTT KPETRAQLAL HSAAFLSAKA AASSSRQMGS QPPLLSRPLP LGSMPTALLA SPPSFPATLH AHQALPVLQA QPLSLVTKSA H (238-587 aa encoded by BC058894)

Target Information

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal.

Cellular & molecular immunology

Wang J,Zhao D,Lei Z,Ge P,Lu Z,Chai Q,Zhang Y,Qiang L,Yu Y,Zhang X,Li B,Zhu S,Zhang L,Liu CH

Wed Feb 01 00:00:00 UTC 2023

Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity.

iScience

He T,Wang S,Li S,Shen H,Hou L,Liu Y,Wei Y,Xie F,Zhang Z,Zhao Z,Mo C,Guo H,Huang Q,Zhang R,Shen D,Li B

Fri Apr 21 00:00:00 UTC 2023

Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells.

Molecular carcinogenesis

Ma Y,Liu L,Wei Z,Zhu M,Huang L,Wang S,Yi X,Ying F,Zhao S,Cai J,Wang Z,Sun S

Sat Apr 01 00:00:00 UTC 2023

Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells.

Molecular carcinogenesis

Ma Y,Liu L,Wei Z,Zhu M,Huang L,Wang S,Yi X,Ying F,Zhao S,Cai J,Wang Z,Sun S

Sat Apr 01 00:00:00 UTC 2023

The WNT/Ca²⁺ pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling in isolated beating rat atria.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Li ZY,Liu Y,Han ZN,Li X,Wang YY,Cui X,Zhang Y

Tue Nov 01 00:00:00 UTC 2022

TCF7L1 regulates cytokine response and neuroendocrine differentiation of prostate cancer.

Oncogenesis

Wen YC,Liu YN,Yeh HL,Chen WH,Jiang KC,Lin SR,Huang J,Hsiao M,Chen WY

Sat Nov 20 00:00:00 UTC 2021

Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.

Nature communications

Hübner K,Cabochette P,Diéguez-Hurtado R,Wiesner C,Wakayama Y,Grassme KS,Hubert M,Guenther S,Belting HG,Affolter M,Adams RH,Vanhollebeke B,Herzog W

Mon Nov 19 00:00:00 UTC 2018

Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.

Nature communications

Hübner K,Cabochette P,Diéguez-Hurtado R,Wiesner C,Wakayama Y,Grassme KS,Hubert M,Guenther S,Belting HG,Affolter M,Adams RH,Vanhollebeke B,Herzog W

Mon Nov 19 00:00:00 UTC 2018

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta.

Stem cell reports

Haider S,Meinhardt G,Saleh L,Kunihs V,Gamperl M,Kaindl U,Ellinger A,Burkard TR,Fiala C,Pollheimer J,Mendjan S,Latos PA,Knöfler M

Tue Aug 14 00:00:00 UTC 2018

Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility.

Endocrinology

Meinhardt G,Haider S,Haslinger P,Proestling K,Fiala C,Pollheimer J,Knöfler M

Thu May 01 00:00:00 UTC 2014

Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility.

Endocrinology

Meinhardt G,Haider S,Haslinger P,Proestling K,Fiala C,Pollheimer J,Knöfler M

Thu May 01 00:00:00 UTC 2014

Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility.

Endocrinology

Meinhardt G,Haider S,Haslinger P,Proestling K,Fiala C,Pollheimer J,Knöfler M

Thu May 01 00:00:00 UTC 2014

Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility.

Endocrinology

Meinhardt G,Haider S,Haslinger P,Proestling K,Fiala C,Pollheimer J,Knöfler M

Thu May 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: HMG box transcription factor 3; T-cell factor 3; TCF-3; transcription factor 3; Transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG box); transcription factor 7-like 1 (T-cell specific, HMG-box); transcription factor 7-like 2 (T-cell specific, HMG box)

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Gene Aliases: bHLHb21; TCF-3; TCF3; TCF7L1

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UniProt ID: (Human) Q9HCS4, (Mouse) Q9Z1J1

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Entrez Gene ID: (Human) 83439, (Rat) 312451, (Mouse) 21415

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Function(s)

DNA binding transcription factor activity, sequence-specific DNA binding beta-catenin binding sequence-specific DNA binding transcription regulatory region DNA binding molecular_function chromatin binding protein binding

Process(es)

biological_process anterior/posterior axis specification, embryo somatic stem cell population maintenance skin development negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter during mitosis axial mesoderm morphogenesis stem cell differentiation canonical Wnt signaling pathway regulation of stem cell population maintenance transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Wnt signaling pathway generation of neurons chromatin organization regulation of Wnt signaling pathway beta-catenin-TCF complex assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TCF7L1 Polyclonal Antibody

TCF7L1 Antibody (14519-1-AP) in IHC (P)

Product Details

14519-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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