Proteintech

TCF7L1/TCF7L2 Monoclonal Antibody (2B2D12), CoraLite® Plus 488

View all (2) TCF7L1/TCF7L2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CL488-67652

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

0.4 µg/1x10^6 cell suspension
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

2B2D12

Immunogen

Recombinant protein
View immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MPQLGGGGGG GGGSGGGGGS SAGAAGGGDD LGANDELIPF QDEGGEEQEP SSDSASAQRD LDEVKSSLVN ESENQSSSSD SEAERRPQPV RDTFQKPRDY FAEVRRPQDS AFFKGPPYPG YPFLMIPDLS SPYLSNGPLS PGGARTYLQM KWPLLDVPSS ATVKDTRSPS PAHLSNKVPV VQHPHHMHPL TPLITYSNDH

Target Information

TCF7L1 is one of TCF/LEF transcription factors that are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It's necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. This antibody raised against 1-200aa of human TCF7L1 can also react with TCF7L2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HMG box transcription factor 3; HMG box transcription factor 4; hTCF-4; mTCF-4; T-cell factor 3; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF-3; TCF7L1/2; transcription factor 3; Transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG box); transcription factor 7-like 1 (T-cell specific, HMG-box); Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG box); transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box

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Gene Aliases: bHLHb21; mTcf-4B; mTcf-4E; TCF-3; TCF-4; TCF3; TCF4; TCF4B; TCF4E; TCF7L1; TCF7L2

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UniProt ID: (Human) Q9HCS4, (Human) Q9NQB0, (Mouse) Q9Z1J1, (Mouse) Q924A0

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Entrez Gene ID: (Human) 83439, (Human) 6934, (Mouse) 21415, (Mouse) 21416

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Function(s)
DNA binding transcription factor activity, sequence-specific DNA binding beta-catenin binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II repressing transcription factor binding protein binding transcription factor binding protein kinase binding nuclear hormone receptor binding gamma-catenin binding armadillo repeat domain binding chromatin binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter blood vessel development cellular glucose homeostasis glycogen metabolic process glucose metabolic process transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell cycle arrest cell proliferation cellular response to starvation response to glucose post-embryonic development positive regulation of triglyceride biosynthetic process positive regulation of heparan sulfate proteoglycan biosynthetic process oligodendrocyte development Wnt signaling pathway neural tube development pituitary gland development bone mineralization negative regulation of BMP signaling pathway embryonic genitalia morphogenesis regulation of myelination positive regulation of insulin secretion positive regulation of protein binding secretory granule localization regulation of hormone metabolic process somatic stem cell population maintenance multicellular organism growth catenin import into nucleus regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter negative regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth glucose homeostasis positive regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity maintenance of DNA repeat elements skin development canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition fat cell differentiation negative regulation of fat cell differentiation positive regulation of gluconeogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of organ growth positive regulation of protein export from nucleus positive regulation of lipid biosynthetic process embryonic digestive tract morphogenesis embryonic hindgut morphogenesis myoblast fate commitment regulation of skeletal muscle tissue development regulation of smooth muscle cell proliferation generation of neurons regulation of oligodendrocyte differentiation positive regulation of epithelial cell proliferation positive regulation of protein kinase B signaling canonical Wnt signaling pathway face morphogenesis regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of canonical Wnt signaling pathway insulin metabolic process negative regulation of type B pancreatic cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway anterior/posterior axis specification, embryo positive regulation of transcription from RNA polymerase II promoter during mitosis axial mesoderm morphogenesis stem cell differentiation regulation of stem cell population maintenance Wnt signaling pathway, calcium modulating pathway pancreas development beta-catenin-TCF complex assembly chromatin organization regulation of Wnt signaling pathway
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