Invitrogen

TCF7L2 Monoclonal Antibody (E.998.2)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-14975

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

-
View 1 publication 1 publication

Immunoprecipitation (IP)

1:50
-

ChIP assay (ChIP)

1:50
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

E.998.2

Immunogen

Synthetic peptide corresponding to residues surrounding Glu81 of human TCF4
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

28 µg/mL

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10979176

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: HMG box transcription factor 4; hTCF; hTCF 4; hTCF-4; RP11-357H24.1; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF 4; TCF7L2 protein; Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box)

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Gene Aliases: TCF-4; TCF4; TCF7L2

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UniProt ID: (Human) Q9NQB0

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Entrez Gene ID: (Human) 6934

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II repressing transcription factor binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding transcription factor binding protein kinase binding nuclear hormone receptor binding sequence-specific DNA binding transcription regulatory region DNA binding gamma-catenin binding armadillo repeat domain binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter blood vessel development transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell cycle arrest Wnt signaling pathway, calcium modulating pathway cell proliferation response to glucose positive regulation of heparan sulfate proteoglycan biosynthetic process pancreas development positive regulation of insulin secretion positive regulation of protein binding regulation of hormone metabolic process glucose homeostasis negative regulation of sequence-specific DNA binding transcription factor activity maintenance of DNA repeat elements canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of protein export from nucleus myoblast fate commitment regulation of smooth muscle cell proliferation positive regulation of protein kinase B signaling canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway beta-catenin-TCF complex assembly negative regulation of type B pancreatic cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway
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