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Abnova
TCIRG1 Polyclonal Antibody, MaxPab™
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Product Details
H00010312-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TCIRG1 (NP_006044.1, 1 a.a. approximately 614 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTFLISYWGE QIGQKIRKIT DCFHCHVFPF LQQEEARLGA LQQLQQQSQE LQEVLGETER FLSQVLGRVL QLLPPGQVQV HKMKAVYLAL NQCSVSTTHK CLIAEAWCSV RDLPALQEAL RDSSMEEGVS AVAHRIPCRD MPPTLIRTNR FTASFQGIVD AYGVGRYQEV NPAPYTIITF PFLFAVMFGD VGHGLLMFLF ALAMVLAENR PAVKAAQNEI WQTFFRGRYL LLLMGLFSIY TGFIYNECFS RATSIFPSGW SVAAMANQSG WSDAFLAQHT MLTLDPNVTG VFLGPYPFGI DPIWSLAANH LSFLNSFKMK MSVILGVVHM AFGVVLGVFN HVHFGQRHRL LLETLPELTF LLGLFGYLVF LVIYKWLCVW AARAASAPSI LIHFINMFLF SHSPSNRLLY PRQEVVQATL VVLALAMVPI LLLGTPLHLL HRHRRRLRRR PADRQEENKA GLLDLPDASV NGWSSDEEKA GGLDDEEEAE LVPSEVLMHQ AIHTIEFCLG CVSNTASYLR LWALSLAHAQ LSEVLWAMVM RIGLGLGREV GVAAVVLVPI FAAFAVMTVA ILLVMEGLSA FLHALRLHWV EFQNKFYSGT GYKLSPFTFA ATDD
Target Information
The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase, H+ transporting, 116kD; OC-116 kDa; Osteoclastic proton pump 116 kDa subunit; specific 116-kDa vacuolar proton pump subunit; T-cell immune regulator 1; T-cell immune response cDNA 7; T-cell immune response cDNA7 protein; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3; TIRC7; V-ATPase 116 kDa subunit a 3; V-ATPase 116-kDa; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a 3; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
Gene Aliases: a3; Atp6i; ATP6N1C; ATP6V0A3; OC-116kDa; OC116; OPTB1; Stv1; TCIRG1; TIRC7; Vph1
UniProt ID: (Human) Q13488
Entrez Gene ID: (Human) 10312
cellular defense response
vacuolar acidification
protein catabolic process in the vacuole
positive regulation of cell proliferation
insulin receptor signaling pathway
ATP synthesis coupled proton transport
ATP hydrolysis coupled proton transport
proton transport
macroautophagy
transferrin transport
ion transmembrane transport
vacuolar proton-transporting V-type ATPase complex assembly
phagosome acidification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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