Proteintech

TCN2 Polyclonal Antibody

TCN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

TCN2 Antibody (12157-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human pancreas cancer tissue slide using (Product # 12157-1-AP) TCN2 antibody at dilution of 1:4,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

12157-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Cat, Dog, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TCN2 Fusion Protein Ag2825 (1-400 aa encoded by BC011239)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MRHLGAFLF LLGVLGALTE MCEIPEMDSH LVEKLGQHLL PWMDRLSLEH LNPSIYVGLR LSSLQAGTKE DLYLHSLKLG YQQCLLGSAF SEDDGDCQGK PSMGQLALYL LALRANWHDH KGHPHTSYYQ YGLGILALCL HQKRVHDSVV DKLLYAVEPF HQGHHSVDTA AMAGLAFTCL KRSNFNPGRR QRITMAIRTV REEILKAQTP EGHFGNVYST PLALQFLMTS PMRGAELGTA CLKARVALLA SLQDGAFQNA LMISQLLPVL NHKTYIDLIF PDCLAPRVML EPAAETIPQT QEIISVTLQV LSLLPPYRQS ISVLAGSTVE DVLKKAHELG GFTYETQASL SGPYLTSVMG KAAGEREFWQ LLRDPNTPLL QGIADYRPKD GETIELRLVS W (1-400 aa encoded by BC011239)

Target Information

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CD320 expression and apical membrane targeting in renal and intestinal epithelial cells.

International journal of biological macromolecules

Chen Y,Gu X,Zhang Y,Zhang X,Zhang C,Liu M,Sun S,Dong N,Wu Q

Tue Mar 15 00:00:00 UTC 2022

Investigation of Receptor-Mediated Cyanocobalamin (Vitamin B₁₂) Transport across the Inner Blood-Retinal Barrier Using Fluorescence-Labeled Cyanocobalamin.

Molecular pharmaceutics

Kinoshita Y,Nogami K,Jomura R,Akanuma SI,Abe H,Inouye M,Kubo Y,Hosoya KI

Mon Aug 06 00:00:00 UTC 2018

Immunohistochemical quantification of the cobalamin transport protein, cell surface receptor and Ki-67 in naturally occurring canine and feline malignant tumors and in adjacent normal tissues.

Oncotarget

Sysel AM,Valli VE,Bauer JA

Tue Feb 10 00:00:00 UTC 2015

Immunohistochemical quantification of the cobalamin transport protein, cell surface receptor and Ki-67 in naturally occurring canine and feline malignant tumors and in adjacent normal tissues.

Oncotarget

Sysel AM,Valli VE,Bauer JA

Tue Feb 10 00:00:00 UTC 2015

Immunohistochemical quantification of the cobalamin transport protein, cell surface receptor and Ki-67 in naturally occurring canine and feline malignant tumors and in adjacent normal tissues.

Oncotarget

Sysel AM,Valli VE,Bauer JA

Tue Feb 10 00:00:00 UTC 2015

Immunohistochemical quantification of the vitamin B12 transport protein (TCII), cell surface receptor (TCII-R) and Ki-67 in human tumor xenografts.

Anticancer research

Sysel AM,Valli VE,Nagle RB,Bauer JA

Tue Oct 01 00:00:00 UTC 2013

Immunohistochemical quantification of the vitamin B12 transport protein (TCII), cell surface receptor (TCII-R) and Ki-67 in human tumor xenografts.

Anticancer research

Sysel AM,Valli VE,Nagle RB,Bauer JA

Tue Oct 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: macrocytic anemia; TC II; TC TC D22S676; TC-2; TCII; Transcobalamin II; transcobalamin II; macrocytic anemia; Transcobalamin-2; vitamin B12-binding protein 2

View more View less

Gene Aliases: AW208754; D22S676; D22S750; II; TC; TC II; TC-2; TC2; TCII; Tcn-2; TCN2; Tcn2p

View more View less

UniProt ID: (Human) P20062, (Mouse) O88968

View more View less

Entrez Gene ID: (Human) 6948, (Mouse) 21452, (Rat) 64365

View more View less

Function(s)

cobalamin binding metal ion binding

Process(es)

transport ion transport cobalt ion transport cobalamin transport cobalamin metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

TCN2 Polyclonal Antibody

TCN2 Antibody (12157-1-AP) in IHC (P)

Product Details

12157-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!