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Invitrogen
TCP-1 beta Polyclonal Antibody
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FIGURE: 1 / 11
TCP-1 beta Antibody (PA5-78952) in ICC/IF
Immunocytochemistry analysis of CCT2 using anti-CCT2 antibody (Product # PA5-78952) . CCT2 was detected in a section of U2OS cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 2μg/mL rabbit anti-CCT2 antibody (Product # PA5-78952) overnight at 4°C. DyLight®488 Conjugated Goat Anti-Rabbit IgG... View More
Product Details
PA5-78952
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human CCT2 recombinant protein (Position: E414-C535).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.01mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746068
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human A549 whole cell, human RT4 whole cell, human CACO-2 whole cell, human 293T whole cell, human MCF-7 whole cell, human HEL whole cell, human Raji whole cell, human SW620 whole cell, rat brain tissue, rat spleen tissue, rat C6 whole cell, rat PC-12 whole cell, mouse brain tissue, mouse spleen tissue, mouse NIH/3T3 whole cell, mouse RAW2647 whole cell. IHC: rat gaster tissue, human testis tissue, mouse gaster tissue. ICC/IF: U20S cell, U2OS cell. Flow: U251 cell.
Target Information
TCP-1 beta is a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). The CCT complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the TCP-1 beta gene have been observed but not thoroughly characterized. A disease associated with TCP-1 beta protein dysfunction include epididymo-orchitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI528772; c-cpn; CCT; CCT-beta; Cct1; Ccta; Chaperonin containing T-complex polypeptide 1 subunit 2; chaperonin containing t-complex polypeptide 1, beta subunit; chaperonin containing t-complex polypeptide 1, subunit 2; chaperonin containing TCP1, subunit 2 (beta); chaperonin subunit 2 (beta); epididymis secretory sperm binding protein Li 100n; p63; T-complex protein 1 subunit beta; T-complex protein 1, beta subunit; Tcp-1; TCP-1-beta; Tp63; TRic
Gene Aliases: 99D8.1; CCT-beta; CCT2; CCTB; HEL-S-100n; PRO1633; TCP-1-beta
UniProt ID: (Human) P78371, (Mouse) P80314, (Rat) Q5XIM9
Entrez Gene ID: (Human) 10576, (Mouse) 12461, (Rat) 299809
protein folding
binding of sperm to zona pellucida
chaperone-mediated protein complex assembly
toxin transport
positive regulation of telomere maintenance via telomerase
protein stabilization
chaperone mediated protein folding independent of cofactor
positive regulation of telomerase activity
scaRNA localization to Cajal body
positive regulation of establishment of protein localization to telomere
positive regulation of protein localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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