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Invitrogen
TCP-1 beta Polyclonal Antibody
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Product Details
PA5-93047
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 206-535 of human TCP1 beta/TCP1 beta/CCT2 (NP_0064221)
Conjugate
Form
Liquid
Concentration
1.26 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2806601
Product Specific Information
Immunogen sequence: GGSLADSYLD EGFLLDKKIG VNQPKRIENA KILIANTGMD TDKIKIFGSR VRVDSTAKVA EIEHAEKEKM KEKVERILKH GINCFINRQL IYNYPEQLFG AAGVMAIEHA DFAGVERLAL VTGGEIASTF DHPELVKLGS CKLIEEVMIG EDKLIHFSGV ALGEACTIVL RGATQQILDE AERSLHDALC VLAQTVKDSR TVYGGGCSEM LMAHAVTQLA NRTPGKEAVA MESYAKALRM LPTIIADNAG YDSADLVAQL RAAHSEGNTT AGLDMREGTI GDMAILGITE SFQVKRQVLL SAAEAAEVIL RVDNIIKAAP RKRVPDHHPC; Positive Samples: MCF7, SKOV3, A-549, HT-29, Mouse spleen, Mouse ovary, Mouse heart; Cellular Location: Cytoplasm
Target Information
TCP-1 beta is a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). The CCT complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the TCP-1 beta gene have been observed but not thoroughly characterized. A disease associated with TCP-1 beta protein dysfunction include epididymo-orchitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI528772; c-cpn; CCT; CCT-beta; Cct1; Ccta; Chaperonin containing T-complex polypeptide 1 subunit 2; chaperonin containing t-complex polypeptide 1, beta subunit; chaperonin containing t-complex polypeptide 1, subunit 2; chaperonin containing TCP1, subunit 2 (beta); chaperonin subunit 2 (beta); epididymis secretory sperm binding protein Li 100n; p63; T-complex protein 1 subunit beta; T-complex protein 1, beta subunit; Tcp-1; TCP-1-beta; Tp63; TRic
Gene Aliases: 99D8.1; CCT-beta; CCT2; CCTB; HEL-S-100n; PRO1633; TCP-1-beta
UniProt ID: (Human) P78371, (Mouse) P80314
Entrez Gene ID: (Human) 10576, (Mouse) 12461
protein folding
binding of sperm to zona pellucida
chaperone-mediated protein complex assembly
toxin transport
positive regulation of telomere maintenance via telomerase
protein stabilization
chaperone mediated protein folding independent of cofactor
positive regulation of telomerase activity
scaRNA localization to Cajal body
positive regulation of establishment of protein localization to telomere
positive regulation of protein localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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