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Product Details
PA5-83181
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TCP1. Recombinant protein control fragment (Product #RP-94733).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2790337
Product Specific Information
Immunogen sequence: VRYINENLIV NTDELGRDCL INAAKTSMSS KIIGINGDFF ANMVVDAVLA IKYTDIRGQP RYPVNSVNIL KAHGRSQMES MLISGY
Target Information
The T Complex Polypeptide 1 (TCP-1) is approximately 60 kDa protein constitutively expressed in almost all eukaryotic cells, and is upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin. The family of proteins termed chaperonins act to recognize and stabilize polypeptide intermediates during folding, assembly and disassembly, and share many characteristics with Heat Shock Protein 70 (HSP70) including high abundance, induction by environmental stress, and ATPase activity. The chaperonin family includes the mitochondrial HSP60, Escherichia coli GroEL, the plastid Rubisco-subunit binding protein, and the archaebacterial protein TF55. The TCP-1 sequence shows nearly 40% identity to TF55, but only minimal similarity to HSP60 and GroEL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCT-alpha; Chaperonin containing T-complex polypeptide 1 subunit 1; T-complex protein 1 subunit alpha; T-complex protein 1, alpha subunit; tailless complex polypeptide 1; TCP-1-alpha
Gene Aliases: CCT-alpha; CCT1; CCTA; D6S230E; TCP-1-alpha; TCP1
UniProt ID: (Human) P17987
Entrez Gene ID: (Human) 6950
protein folding
tubulin complex assembly
binding of sperm to zona pellucida
positive regulation of telomere maintenance via telomerase
translocation of peptides or proteins into host cell cytoplasm
protein stabilization
positive regulation of telomerase activity
scaRNA localization to Cajal body
toxin transport
positive regulation of establishment of protein localization to telomere
positive regulation of protein localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
regulation of macrophage apoptotic process
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