Product References
Ex vivo assays show human gamma-delta T cells specific for common allergens are Th1-polarized in allergic donors.
Cell reports methods
Yu ED,Wang E,Garrigan E,Sutherland A,Khalil N,Kearns K,Pham J,Schulten V,Peters B,Frazier A,Sette A,da Silva Antunes R
TCR2730 was used in flow cytometry to support the existence of allergen-reactive γδ T cells and their potential use in rebalancing dysregulated Th2 responses in allergic diseases.
Mon Dec 19 00:00:00 UTC 2022
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
TCR2730 was used in Flow Cytometry to demonstrate the role of the dendritic cells-based mechanical regulation of immunopathology in directing T cell lineage commitment in tumor microenvironments.
Mon Aug 22 00:00:00 UTC 2022
Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples.
Nature communications
Liechti T,Iftikhar Y,Mangino M,Beddall M,Goss CW,O'Halloran JA,Mudd PA,Roederer M
TCR2730 was used in Flow cytometry/Cell sorting to identify potential immune mechanisms contributing to severe COVID-19.
Fri Nov 25 00:00:00 UTC 2022
PECAM-1 Is Down-Regulated in γδT Cells during Remission, but Up-Regulated in Relapse of Multiple Sclerosis.
Journal of clinical medicine
Zarobkiewicz MK,Morawska I,Kowalska W,Halczuk P,Roliński J,Bojarska-Junak AA
TCR2730 was used in Flow cytometry/Cell sorting to study analysis of PECAM-1 and NKRP1A expression on γδ T cells.
Sat Jun 04 00:00:00 UTC 2022
Defining TCRγδ lymphoproliferative disorders by combined immunophenotypic and molecular evaluation.
Nature communications
Teramo A,Binatti A,Ciabatti E,Schiavoni G,Tarrini G,Barilà G,Calabretto G,Vicenzetto C,Gasparini VR,Facco M,Petrini I,Grossi R,Pisanti N,Bortoluzzi S,Falini B,Tiacci E,Galimberti S,Semenzato G,Zambello R
TCR2730 was used in Flow cytometry/Cell sorting to show that an association between Vδ2/Vγ9 clonality and indolent course, while Vδ2/Vγ9 negativity correlates with symptomatic disease.
Wed Jun 08 00:00:00 UTC 2022
Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage.
Cell host & microbe
Seki D,Mayer M,Hausmann B,Pjevac P,Giordano V,Goeral K,Unterasinger L,Klebermaß-Schrehof K,De Paepe K,Van de Wiele T,Spittler A,Kasprian G,Warth B,Berger A,Berry D,Wisgrill L
TCR2730 was used in Flow cytometry/Cell sorting to suggest that aberrant development of the gut-microbiota-immune-brain axis may drive or exacerbate brain injury in extremely premature neonates and represents a promising target for novel intervention strategies.
Wed Oct 13 00:00:00 UTC 2021
High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile.
Cell reports
Wragg KM,Tan HX,Kristensen AB,Nguyen-Robertson CV,Kelleher AD,Parsons MS,Wheatley AK,Berzins SP,Pellicci DG,Kent SJ,Juno JA
TCR2730 was used in Flow Cytometry to demonstrate if CD26 and CD94 define transcriptionally, phenotypically, and functionally distinct Vδ2+ T cell subsets.
Tue Jun 16 00:00:00 UTC 2020
Analysis of colon-infiltrating γδ T cells in chronic inflammatory bowel disease and in colitis-associated cancer.
Journal of leukocyte biology
Lo Presti E,Mocciaro F,Mitri RD,Corsale AM,Di Simone M,Vieni S,Scibetta N,Unti E,Dieli F,Meraviglia S
TCR2730 was used in Flow cytometry/Cell sorting to demonstrate that Vδ2 T cells have a proinflammatory profile in chronic IBD are suggestive of their participation in IBD and CAC pathogenesis.
Sat Aug 01 00:00:00 UTC 2020
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.
Cell
Mayassi T,Ladell K,Gudjonson H,McLaren JE,Shaw DG,Tran MT,Rokicka JJ,Lawrence I,Grenier JC,van Unen V,Ciszewski C,Dimaano M,Sayegh HE,Kumar V,Wijmenga C,Green PHR,Gokhale R,Jericho H,Semrad CE,Guandalini S,Dinner AR,Kupfer SS,Reid HH,Barreiro LB,Rossjohn J,Price DA,Jabri B
TCR2730 was used in Flow cytometry/Cell sorting to determine the role of tissue-resident lymphocytes in chronic inflammation.
Thu Feb 21 00:00:00 UTC 2019
Tumor infiltrating lymphocytes expanded from pediatric neuroblastoma display heterogeneity of phenotype and function.
PloS one
Ollé Hurtado M,Wolbert J,Fisher J,Flutter B,Stafford S,Barton J,Jain N,Barone G,Majani Y,Anderson J
TCR2730 was used in Flow cytometry/Cell sorting to determine the function of tumour infiltrating lymphocytes in cancer types.
Fri Feb 28 00:00:00 UTC 2020
Natural Killer Cells Exhibit a Peculiar Phenotypic Profile in Systemic Sclerosis and Are Potent Inducers of Endothelial Microparticles Release.
Frontiers in immunology
Benyamine A,Magalon J,Sabatier F,Lyonnet L,Robert S,Dumoulin C,Morange S,Mazodier K,Kaplanski G,Reynaud-Gaubert M,Rossi P,Dignat-George F,Granel B,Paul P
TCR2730 was used in Flow cytometry/Cell sorting to quantify circulating cytotoxic immune cells and their expression of CX3CR1 in systemic sclerosis.
Wed Nov 20 00:00:00 UTC 2019
Increased frequency of systemic pro-inflammatory Vδ1+ γδ T cells in HIV elite controllers correlates with gut viral load.
Scientific reports
Olson GS,Moore SW,Richter JM,Garber JJ,Bowman BA,Rawlings CA,Flagg M,Corleis B,Kwon DS
TCR2730 was used in Flow cytometry/Cell sorting to support a model in which local viral replication in the gut in HIV controllers disrupts the phenotype and function of Vδ1+ cells, a cell type involved in the maintenance of epithelial barrier integrity, and may thereby contribute to systemic immune activation and HIV disease progression.
Wed Nov 07 00:00:00 UTC 2018
Secretion of autoimmune antibodies in the human subcutaneous adipose tissue.
PloS one
Frasca D,Diaz A,Romero M,Thaller S,Blomberg BB
TCR2730 was used in Flow cytometry/Cell sorting to demonstrate novel mechanisms for the generation of autoimmune antibody responses in human subcutaneous adipose tissue.
Mon Nov 26 00:00:00 UTC 2018
Syphilis Infection Differentially Regulates the Phenotype and Function of γδ T Cells in HIV-1-Infected Patients Depends on the HIV-1 Disease Stage.
Frontiers in immunology
Li Z,Lu X,Hu Z,Luo Z,Jiang W,Wu H,Gao Y,Yan J,Zhang Q,Song A,Huang X,Mou D,Su B,Zhang T
TCR2730 was used in Flow cytometry/Cell sorting to suggest that the γδ T-cell/IL-17/neutrophil axis is involved in HIV-1 pathogenesis and disease progression.
Wed Nov 20 00:00:00 UTC 2019
CD11d β2 integrin expression on human NK, B, and γδ T cells.
Journal of leukocyte biology
Siegers GM,Barreira CR,Postovit LM,Dekaban GA
TCR2730 was used in flow cytometry to measure CD11d expression on lymphocyte subsets using flow cytometry
Sat Apr 01 00:00:00 UTC 2017
Characterization of γδ T cells in patients with non-small cell lung cancer.
Oncology letters
Bao Y,Guo L,Mo J
Published figure using TCR V delta 1 monoclonal antibody (Product # TCR2730) in Flow Cytometry
Sat Jul 01 00:00:00 UTC 2017
Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre
Kim JM,Kwon CHD,Joh JW,Sinn DH,Choi GS,Park JB,Kang ES,Lee SK
TCR2730 was used in flow cytometry to characterize the periferal blood lymphocytes phenotype in tacrolimus-treated liver transplanted patients.
Mon Mar 19 00:00:00 UTC 2018
E. coli promotes human Vγ9Vδ2 T cell transition from cytokine-producing bactericidal effectors to professional phagocytic killers in a TCR-dependent manner.
Scientific reports
Barisa M,Kramer AM,Majani Y,Moulding D,Saraiva L,Bajaj-Elliott M,Anderson J,Gustafsson K
TCR2730 was used in Flow cytometry/Cell sorting to conclude that γδT cells transition from early inflammatory cytotoxic killers to myeloid-like APC in response to infectious stimuli.
Mon Jun 05 00:00:00 UTC 2017
Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments.
Cell
Di Marco Barros R,Roberts NA,Dart RJ,Vantourout P,Jandke A,Nussbaumer O,Deban L,Cipolat S,Hart R,Iannitto ML,Laing A,Spencer-Dene B,East P,Gibbons D,Irving PM,Pereira P,Steinhoff U,Hayday A
TCR2730 was used in flow cytometry investigate how organ-specific Btnl genes shape local T cell compartments
Thu Sep 22 00:00:00 UTC 2016
A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells.
Cellular & molecular immunology
Mao Y,Yin S,Zhang J,Hu Y,Huang B,Cui L,Kang N,He W
TCR2730 was used in Immunocytochemistry-immunoflourescence to demonstrate a negative regulatory role of interleukin 4 in gamma delta cell-mediated anti-tumour immunity.
Tue Mar 01 00:00:00 UTC 2016
CD8αβ+ γδ T Cells: A Novel T Cell Subset with a Potential Role in Inflammatory Bowel Disease.
Journal of immunology (Baltimore, Md. : 1950)
Kadivar M,Petersson J,Svensson L,Marsal J
TCR2730 was used in flow cytometry to characterize CD8 positive alpha beta gamma delta T cells
Thu Dec 15 00:00:00 UTC 2016
Effective combination treatment of GD2-expressing neuroblastoma and Ewing's sarcoma using anti-GD2 ch14.18/CHO antibody with Vγ9Vδ2+ γδT cells.
Oncoimmunology
Fisher JP,Flutter B,Wesemann F,Frosch J,Rossig C,Gustafsson K,Anderson J
TCR2730 was used in Flow cytometry/Cell sorting to evaluate in vitro cytotoxicity and tumor growth inhibition in the GD2 expressing cancers neuroblastoma and Ewing's sarcoma.
Sat Feb 10 00:00:00 UTC 2024
Distortion of memory Vδ2 γδ T cells contributes to immune dysfunction in chronic HIV infection.
Cellular & molecular immunology
Li Z,Jiao Y,Hu Y,Cui L,Chen D,Wu H,Zhang J,He W
TCR2730 was used in Flow cytometry/Cell sorting to study the biological mechanisms and clinical consequences of Vδ(1) T cells and Vδ(2) T cell disruption.
Tue Sep 01 00:00:00 UTC 2015
γδ T cell activation by bispecific antibodies.
Cellular immunology
Oberg HH,Kellner C,Gonnermann D,Peipp M,Peters C,Sebens S,Kabelitz D,Wesch D
TCR2730 was used in flow cytometry to evaluate the therapeutic potential of a gammatheta T cell-targeting tribody for tumor immunotherapy
Wed Jul 01 00:00:00 UTC 2015
Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity.
Oncoimmunology
Gonnermann D,Oberg HH,Kellner C,Peipp M,Sebens S,Kabelitz D,Wesch D
TCR2730 was used in Flow cytometry/Cell sorting to show that differences between PDAC cells in regards to sensitivity to γδ T-cell cytotoxicity can be due to distinct levels of Cox-2 expression associated with varying amounts of PGE2 release.
Sun Mar 01 00:00:00 UTC 2015
Enhanced functions of peripheral γδ T cells in chronic hepatitis B infection during interferon α treatment in vivo and in vitro.
PloS one
Chen M,Hu P,Ling N,Peng H,Lei Y,Hu H,Zhang D,Ren H
TCR2730 was used in Flow cytometry/Cell sorting to investigate the changes in phenotype and function of peripheral γδ T cells in patients with chronic hepatitis B during pegylated-interferon-α treatment.
Fri Oct 16 00:00:00 UTC 2015
Primary and Chronic HIV Infection Differently Modulates Mucosal Vδ1 and Vδ2 T-Cells Differentiation Profile and Effector Functions.
PloS one
Cimini E,Agrati C,D'Offizi G,Vlassi C,Casetti R,Sacchi A,Lionetti R,Bordoni V,Tumino N,Scognamiglio P,Martini F
TCR2730 was used in flow cytometry to characterize gut-associated gammadelta T-cells in HIV-infected individuals.
Thu Apr 14 00:00:00 UTC 2016
Neuroblastoma killing properties of Vδ2 and Vδ2-negative γδT cells following expansion by artificial antigen-presenting cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Fisher JP,Yan M,Heuijerjans J,Carter L,Abolhassani A,Frosch J,Wallace R,Flutter B,Capsomidis A,Hubank M,Klein N,Callard R,Gustafsson K,Anderson J
TCR2730 was used in flow cytometry to discuss blood gammadeltaT subsets and their potential role in cancer immunotherapy
Sat Nov 15 00:00:00 UTC 2014
Novel bispecific antibodies increase γδ T-cell cytotoxicity against pancreatic cancer cells.
Cancer research
Oberg HH,Peipp M,Kellner C,Sebens S,Krause S,Petrick D,Adam-Klages S,Röcken C,Becker T,Vogel I,Weisner D,Freitag-Wolf S,Gramatzki M,Kabelitz D,Wesch D
TCR2730 was used in flow cytometry to study the cytotoxicity of gammadelta T-cells towards pancreatic cancer cells mediated by bispecific antibodies that selectively recruit to tumor antigens
Sat Mar 01 00:00:00 UTC 2014
Human γδ thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling.
Journal of immunology (Baltimore, Md. : 1950)
Ribot JC,Ribeiro ST,Correia DV,Sousa AE,Silva-Santos B
TCR2730 was used in Flow Cytometry to study how ex vivo-isolated γδ thymocytes produced negligible IFN-γ and lacked cytolytic activity against leukemia cells.
Sat Mar 01 00:00:00 UTC 2014
Characterization of γδT cells in naïve and HIV-infected chimpanzees and their responses to T-cell activators in vitro.
Journal of medical primatology
Hodara VL,Parodi LM,Chavez D,Smith LM,Lanford R,Giavedoni LD
TCR2730 was used in flow cytometry to study the in vitro response of gammadelta T-cell subsets from HIV1-infected and control chimpanzees to T-cell activators
Fri Aug 01 00:00:00 UTC 2014
CD1d-lipid antigen recognition by the γδ TCR.
Nature immunology
Uldrich AP,Le Nours J,Pellicci DG,Gherardin NA,McPherson KG,Lim RT,Patel O,Beddoe T,Gras S,Rossjohn J,Godfrey DI
TCR2730 was used in immunocytochemistry to study the mechanism by which the gamma delta TCR recognizes CD1d loaded with alpha-galactosylceramide
Fri Nov 01 00:00:00 UTC 2013
Extensive expansion of primary human gamma delta T cells generates cytotoxic effector memory cells that can be labeled with Feraheme for cellular MRI.
Cancer immunology, immunotherapy : CII
Siegers GM,Ribot EJ,Keating A,Foster PJ
TCR2730 was used in blocking or activating experiment to develop a method for the extensive expansion of gamma delta T-cells to be labelled with Feraheme for use in cellular MRI studies
Fri Mar 01 00:00:00 UTC 2013
Donor Vδ1+ γδ T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL.
Experimental hematology & oncology
Prinz I,Thamm K,Port M,Weissinger EM,Stadler M,Gabaev I,Jacobs R,Ganser A,Koenecke C
TCR2730 was used in flow cytometry to present the case of a 48-year-old man who received allogeneic stem cell transplantation for progressive B-CLL
Sat May 11 00:00:00 UTC 2013
Maternal Foxp3 expressing CD4+ CD25+ and CD4+ CD25- regulatory T-cell populations are enriched in human early normal pregnancy decidua: a phenotypic study of paired decidual and peripheral blood samples.
American journal of reproductive immunology (New York, N.Y. : 1989)
Dimova T,Nagaeva O,Stenqvist AC,Hedlund M,Kjellberg L,Strand M,Dehlin E,Mincheva-Nilsson L
TCR2730 was used in immunohistochemistry to identify relationship between T-cell populations and pregnancy
Fri Jul 01 00:00:00 UTC 2011
Human gammadelta T cells produce the protease inhibitor and antimicrobial peptide elafin.
Scandinavian journal of immunology
Marischen L,Wesch D,Schröder JM,Wiedow O,Kabelitz D
TCR2730 was used in Flow Cytometry to reveal a novel effector function of gammadelta T cells which might be important for local immune defence.
Tue Dec 01 00:00:00 UTC 2009
V-chain preference of gamma/delta T-cell receptors in peripheral blood during term labor.
American journal of reproductive immunology (New York, N.Y. : 1989)
Barakonyi A,Miko E,Varga P,Szekeres-Bartho J
TCR2730 was used in flow cytometry to study the role of Vgamma and Vdelta chains in peripheral gamma/delta T cells during labor
Sat Mar 01 00:00:00 UTC 2008
Recognition of nonpeptide antigens by human V gamma 9V delta 2 T cells requires contact with cells of human origin.
Clinical and experimental immunology
Green AE,Lissina A,Hutchinson SL,Hewitt RE,Temple B,James D,Boulter JM,Price DA,Sewell AK
TCR2730 was used in flow cytometry to study gamma delta T cell activation
Tue Jun 01 00:00:00 UTC 2004
Flexible migration program regulates gamma delta T-cell involvement in humoral immunity.
Blood
Brandes M,Willimann K,Lang AB,Nam KH,Jin C,Brenner MB,Morita CT,Moser B
TCR2730 was used in immunohistochemistry to investigate the migration of gamma delta T cells
Sat Nov 15 00:00:00 UTC 2003
Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood gammadelta T cells despite suppressive therapy.
Journal of virology
Poles MA,Barsoum S,Yu W,Yu J,Sun P,Daly J,He T,Mehandru S,Talal A,Markowitz M,Hurley A,Ho D,Zhang L
TCR2730 was used in flow cytometry to study the role of HIV-1 infection in mucosal and blood gamma-delta T Cells
Wed Oct 01 00:00:00 UTC 2003
gammadelta T-cell anergy in human immunodeficiency virus-infected persons with opportunistic infections and recovery after highly active antiretroviral therapy.
Immunology
Martini F,Urso R,Gioia C,De Felici A,Narciso P,Amendola A,Paglia MG,Colizzi V,Poccia F
TCR2730 was used in flow cytometry to investigate gammadelta T cells in HIV-infected individuals
Tue Aug 01 00:00:00 UTC 2000
