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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • TCR beta Antibodies

          Invitrogen

          TCR beta Monoclonal Antibody (H57-597)

          29 References
          View all (41) TCR beta antibodies
          Datasheet
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          Datasheet
          Protocols
          Questions & Answers

          Cite TCR beta Monoclonal Antibody (H57-597)

          • Antibody Testing Data (1)
          TCR beta Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.
          TCR beta Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          TCR beta Antibody (MA1-70045) in Flow

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          TCR beta Antibody in Flow Cytometry (Flow)

          Product Details

          MA1-70045

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          -

          Immunohistochemistry (Frozen) (IHC (F))

          Assay-dependent
          -

          Immunocytochemistry (ICC/IF)

          -
          View 1 publication 1 publication

          Flow Cytometry (Flow)

          1 µg/1 million cells
          View 17 publications 17 publications

          Immunoprecipitation (IP)

          Assay-dependent
          -

          Miscellaneous PubMed (MISC)

          -
          View 11 publications 11 publications
          Product Specifications

          Species Reactivity

          Mouse

          Published species

          Mouse

          Host/Isotype

          Armenian hamster / IgG

          Class

          Monoclonal

          Type

          Antibody

          Clone

          H57-597

          Immunogen

          Affinity purified D0 -11.10 TCR.

          Conjugate

          Unconjugated Unconjugated Unconjugated
          • Biotin 
          • FITC
          • PE 
          • Request custom conjugation

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein G

          Storage buffer

          PBS

          Contains

          0.02% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_1087723

          Product Specific Information

          MA1-70045 detects alpha/beta TCR in mouse samples.

          MA1-70045 has been successfully used in flow cytometry, immunoprecipitation, immunohistochemistry (frozen sections), and Western blot procedures.

          The MA1-70045 immunogen is affinity purified D0 -11.10 TCR.

          Stable at 4ºC. For long term storage, aliquot and freeze unused portions at -20ºC in volumes appropriate for single usage. Avoid repeated freeze/thaw cycles.

          Target Information

          The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; TCRbeta; TCRD; TRA

          View more View less

          Gene Aliases: TCRbeta; Tib

          View more View less

          Entrez Gene ID: (Mouse) 21577

          View more View less

          It has to be done as per old AB suggested Products section.
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          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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