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Invitrogen
TDP1 Polyclonal Antibody
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Product Details
PA5-98189
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Tyrosyl-DNA phosphodiesterase 1 protein (1-260AA)
Conjugate
Form
Liquid
Concentration
2.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2812803
Target Information
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein expressed in male leptotene and zygotene spermatocytes 501; Tyr-DNA phosphodiesterase 1; tyrosyl-DNA phodphodiesterase 1; Tyrosyl-DNA phosphodiesterase 1
Gene Aliases: 2810481F14Rik; 4921509N21Rik; AI838772; AW493413; E430034L06Rik; MLZ-501; SCAN1; TDP1
UniProt ID: (Human) Q9NUW8, (Rat) Q4G056
Entrez Gene ID: (Human) 55775, (Rat) 314380, (Mouse) 104884
double-stranded DNA binding
single-stranded DNA binding
exonuclease activity
protein binding
3'-tyrosyl-DNA phosphodiesterase activity
molecular_function
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
photoreceptor cyclic-nucleotide phosphodiesterase activity
nuclease activity
phosphoric diester hydrolase activity
hydrolase activity
7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity
inositol phosphosphingolipid phospholipase activity
inositol phosphorylceramide phospholipase activity
mannosyl-inositol phosphorylceramide phospholipase activity
mannosyl-diinositol phosphorylceramide phospholipase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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