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Invitrogen
TEAD1/2/3/4 Recombinant Rabbit Monoclonal Antibody (23GB4680)
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FIGURE: 1 / 3
TEAD1/2/3/4 Antibody (MA5-52728) in ICC/IF
Immunocytochemistry analysis of TEAD1/2/3/4 in HepG2 cells. Nuclei were stained blue with DAPI; TEAD1/2/3/4 recombinant monoclonal antibody (Product # MA5-52728) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Product Details
MA5-52728
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB4680
Immunogen
A synthesized peptide derived from human TEAD1+TEAD2+TEAD3+TEAD4 (150-300AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3249205
Target Information
TEAD1, TEAD2, TEAD3, and TEAD4 are members of the TEAD (TEA domain) family of transcription factors. These factors are known to play important roles in various biological processes, including development, cell proliferation, differentiation, and organogenesis.| TEAD1, TEAD2, TEAD3, and TEAD4 exhibit overlapping but also distinct expression patterns and functions. They are involved in diverse cellular processes and have been implicated in the regulation of embryonic development, tissue homeostasis, cell fate determination, and tumor progression. | TEAD proteins are known to interact with various co-factors, including the transcriptional co-activators YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif), which play crucial roles in the Hippo signaling pathway. The interaction between TEAD and YAP/TAZ is essential for the activation of downstream target genes involved in cell proliferation and survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DTEF-1; ETF; ETFR-1; NTEF-1; Protein GT-IIC; RTEF-1; RTEF1; TCF-13; TCF13; TEA Domain Family Member 1; TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor); TEA Domain Family Member 2; TEA Domain Family Member 3; TEA Domain Family Member 5; TEA Domain Transcription Factor 1; TEA Domain Transcription Factor 2; TEA Domain Transcription Factor 3; TEAD; TEAD-1; TEAD-2; TEAD-3; TEAD-4; TEAD2; TEAD3; TEAD5; TEF-4; TEF-5; TEF3; TEF4; TEF5; Transcription Factor 13; Transcriptional Enhancer Factor 1; Transcriptional Enhancer Factor 1-Related; Transcriptional Enhancer Factor 5; Transcriptional Enhancer Factor TEF-1; Transcriptional Enhancer Factor TEF-4; Transcriptional Enhancer Factor TEF-5; Transcriptional Enhancer Factor TEF-5 (DTEF-1)
Gene Aliases: AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1; TEAD1; TEF-1; TEF1
UniProt ID: (Human) P28347
Entrez Gene ID: (Human) 7003, (Rat) 361630
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
core promoter proximal region DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
embryonic heart tube morphogenesis
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
heart development
transition between fast and slow fiber
notochord development
hippo signaling
regulation of cell proliferation
positive regulation of transcription from RNA polymerase II promoter
paraxial mesoderm development
lateral mesoderm development
cellular response to retinoic acid
positive regulation of protein serine/threonine kinase activity
positive regulation of stem cell population maintenance
transcription initiation from RNA polymerase II promoter
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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