Proteintech

TEAD4 Polyclonal Antibody

FIGURE: 1 / 5

TEAD4 Antibody (12418-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 12418-1-AP) (TEAD4 antibody) at dilution of 1:1,500 incubated at room temperature for 1.5 hours.

TEAD4 Antibody in Immunoprecipitation (IP)

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Product Details

12418-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TEAD4 Fusion Protein Ag3059 (135-434 aa encoded by BC015497)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SAQIISATA FHSSMALARG PGRPAVSGFW QGALPGQAGT SHDVKPFSQQ TYAVQPPLPL PGFESPAGPA PSPSAPPAPP WQGRSVASSK LWMLEFSAFL EQQQDPDTYN KHLFVHIGQS SPSYSDPYLE AVDIRQIYDK FPEKKGGLKD LFERGPSNAF FLVKFWADLN TNIEDEGSSF YGVSSQYESP ENMIITCSTK VCSFGKQVVE KVETEYARYE NGHYSYRIHR SPLCEYMINF IHKLKHLPEK YMMNSVLENF TILQVVTNRD TQETLLCIAY VFEVSASEHG AQHHIYRLVK E (135-434 aa encoded by BC015497)

Target Information

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Long noncoding RNA Malat1 inhibits Tead3-Nfatc1-mediated osteoclastogenesis to suppress osteoporosis and bone metastasis.

Research square

Zhao Y,Teng H,Deng Y,Sheldon M,Martinez C,Zhang J,Tian A,Sun Y,Nakagawa S,Yao F,Wang H,Ma L

Mon Mar 20 00:00:00 UTC 2023

Tea domain transcription factor TEAD4 mitigates TGF-β signaling and hepatocellular carcinoma progression independently of YAP.

Journal of molecular cell biology

Luo W,Li Y,Zeng Y,Li Y,Cheng M,Zhang C,Li F,Wu Y,Huang C,Yang X,Kremerskothen J,Zhang J,Zhang C,Tu S,Li Z,Luo Z,Lin Z,Yan X

Tue Jun 13 00:00:00 UTC 2023

Tea domain transcription factor TEAD4 mitigates TGF-β signaling and hepatocellular carcinoma progression independently of YAP.

Journal of molecular cell biology

Luo W,Li Y,Zeng Y,Li Y,Cheng M,Zhang C,Li F,Wu Y,Huang C,Yang X,Kremerskothen J,Zhang J,Zhang C,Tu S,Li Z,Luo Z,Lin Z,Yan X

Tue Jun 13 00:00:00 UTC 2023

YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells.

MedComm

Wang P,Huang L,Yang F,Chen W,Bai D,Guo Y

Thu Jun 01 00:00:00 UTC 2023

KIAA1429-mediated m6A modification of CHST11 promotes progression of diffuse large B-cell lymphoma by regulating Hippo-YAP pathway.

Cellular & molecular biology letters

Chen X,Lu T,Cai Y,Han Y,Ding M,Chu Y,Zhou X,Wang X

Wed Apr 19 00:00:00 UTC 2023

A yes-associated protein 1- Notch1 receptor positive feedback loop promotes breast cancer lung metastasis by attenuating the bone morphogenetic protein 4-SMAD family member 1/5 signaling.

Carcinogenesis

Zhao L,Lei J,Gu S,Zhang Y,Jing X,Wang L,Zhang L,Ning Q,Luo M,Qi Y,Zhao X,Shao S

Sat Dec 31 00:00:00 UTC 2022

TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer.

Journal of experimental & clinical cancer research : CR

Chi M,Liu J,Mei C,Shi Y,Liu N,Jiang X,Liu C,Xue N,Hong H,Xie J,Sun X,Yin B,Meng X,Wang B

Tue May 17 00:00:00 UTC 2022

NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop.

Journal of cellular and molecular medicine

Hu B,Zhou S,Hu X,Zhang H,Lan X,Li M,Wang Y,Hu Q

Thu Jul 01 00:00:00 UTC 2021

NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop.

Journal of cellular and molecular medicine

Hu B,Zhou S,Hu X,Zhang H,Lan X,Li M,Wang Y,Hu Q

Thu Jul 01 00:00:00 UTC 2021

YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.

Molecular carcinogenesis

Li Y,Zhu X,Yang M,Wang Y,Li J,Fang J,Guo W,Ma S,Guan F

Thu Jul 01 00:00:00 UTC 2021

Systematic screening identifies a TEAD4-S100A13 axis modulating cisplatin sensitivity of oral squamous cell carcinoma cells.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Li R,Li W,He F,Zhang M,Luo H,Tang H

Fri Oct 01 00:00:00 UTC 2021

Down-regulation of interferon regulatory factor 2 binding protein 2 suppresses gastric cancer progression by negatively regulating connective tissue growth factor.

Journal of cellular and molecular medicine

Yao Y,Wang Y,Li L,Xiang X,Li J,Chen J,Liu Z,Huang S,Xiong J,Deng J

Sun Dec 01 00:00:00 UTC 2019

Thyroid hormone regulates muscle fiber type conversion via miR-133a1.

The Journal of cell biology

Zhang D,Wang X,Li Y,Zhao L,Lu M,Yao X,Xia H,Wang YC,Liu MF,Jiang J,Li X,Ying H

Mon Dec 22 00:00:00 UTC 2014

Thyroid hormone regulates muscle fiber type conversion via miR-133a1.

The Journal of cell biology

Zhang D,Wang X,Li Y,Zhao L,Lu M,Yao X,Xia H,Wang YC,Liu MF,Jiang J,Li X,Ying H

Mon Dec 22 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: ETF-related factor 2; ETF-related factor-2; ETFR-2; FGF-regulated 19; related transcription enhancer factor 1B; RTEF-1; TEA domain family member 4; TEAD-4; TEF-1-related factor 1; TEF-1-related factor FR-19; Transcription factor 13-like 1; Transcription factor RTEF-1; transcriptional enhancer factor 1-related; transcriptional enhancer factor 3; Transcriptional enhancer factor TEF-3

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Gene Aliases: EFTR-2; ETFR-2; Etfr2; FR-19; hRTEF-1B; RTEF1; TCF13L1; Tcf13r1; TEAD-4; TEAD4; TEF-3; TEF3; Tefr; TEFR-1; Tefr1; Tefr1a

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UniProt ID: (Human) Q15561, (Mouse) Q62296

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Entrez Gene ID: (Human) 7004, (Mouse) 21679, (Rat) 683522

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Function(s)

DNA binding transcription factor activity, sequence-specific DNA binding protein binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding sequence-specific DNA binding

Process(es)

in utero embryonic development cell fate specification blastocyst formation trophectodermal cell fate commitment positive regulation of defense response to virus by host transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter embryo implantation hippo signaling cell fate commitment positive regulation of transcription from RNA polymerase II promoter positive regulation of stem cell population maintenance skeletal system development transcription initiation from RNA polymerase II promoter muscle organ development xenophagy

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TEAD4 Polyclonal Antibody

TEAD4 Antibody (12418-1-AP) in WB

Product Details

12418-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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