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Product Details
H00007010-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TEK (ABW03349.1, 1 a.a. approximately 1101 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDLILINSLP LVSDAETSLT CIASGWRPHE PITIGRDFEA LMNQHQDPLE VTQDVTREWA KKVVWKREKA SKINGAYFCE GRVRGEAIRI RTMKMRQQAS FLPATLTMTV DKGDNVNISF KKVLIKEEDA VIYKNGSFIH SVPRHEVPDI LEVHLPHAQP QDAGVYSARY IGGNLFTSAF TRLIVRRCEA QKWGPECNHL CTACMNNGVC HEDTGECICP PGFMGRTCEK ACELHTFGRT CKERCSGQEG CKSYVFCLPD PYGCSCATGW KGLQCNEACH PGFYGPDCKL RCSCNNGEMC DRFQGCLCSP GWQGLQCERE GIPRMTPKIV DLPDHIEVNS GKFNPICKAS GWPLPTNEEM TLVKPDGTVL HPKDFNHTDH FSVAIFTIHR ILPPDSGVWV CSVNTVAGMV EKPFNISVKV LPKPLNAPNV IDTGHNFAVI NISSEPYFGD GPIKSKKLLY KPVNHYEAWQ HIQVTNEIVT LNYLEPRTEY ELCVQLVRRG EGGEGHPGPV RRFTTASIGL PPPRGLNLLP KSQTTLNLTW QPIFPSSEDD FYVEVERRSV QKSDQQNIKV PGNLTSVLLN NLHPREQYVV RARVNTKAQG EWSEDLTAWT LSDILPPQPE NIKISNITHS SAVISWTILD GYSISSITIR YKVQGKNEDQ HVDVKIKNAT ITQYQLKGLE PETAYQVDIF AENNIGSSNP AFSHELVTLP ESQAPADLGG GKMLLIAILG SAGMTCLTVL LAFLIILQLK RANVQRRMAQ AFQNVREEPA VQFNSGTLAL NRKVKNNPDP TIYPVLDWND IKFQDVIGEG NFGQVLKARI KKDGLRMDAA IKRMKEYASK DDHRDFAGEL EVLCKLGHHP NIINLLGACE HRGYLYLAIE YAPHGNLLDF LRKSRVLETD PAFAIANSTA STLSSHHLLH FAADVARGMD YLSQKQFIHR DLAARNILVG ENYVAKIADF GLSRGQEVYV KKTMGRLPVR WMAIESLNYS VYTTNSDVWS YGVLLWEIVS LGGTPYCGMT CAELYEKLPQ GYRLEKPLNC DDEVYDLMRQ CWREKPYERP SFAQILVSLN RMLEERKTYV NTTLYEKFTY AGIDCSAEEA A
Target Information
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Angiopoietin-1 receptor; CD202b; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; hTIE2; p140 TEK; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2
Gene Aliases: CD202B; TEK; TIE-2; TIE2; VMCM; VMCM1
UniProt ID: (Human) Q02763
Entrez Gene ID: (Human) 7010
MAPK cascade
angiogenesis
response to hypoxia
positive regulation of protein phosphorylation
endothelial cell proliferation
positive regulation of endothelial cell proliferation
endochondral ossification
sprouting angiogenesis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell-cell signaling
heart development
positive regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
negative regulation of angiogenesis
peptidyl-tyrosine phosphorylation
organ regeneration
regulation of establishment or maintenance of cell polarity
substrate adhesion-dependent cell spreading
negative regulation of apoptotic process
regulation of vascular permeability
response to peptide hormone
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
response to estrogen
positive regulation of angiogenesis
protein autophosphorylation
Tie signaling pathway
negative regulation of inflammatory response
leukocyte migration
protein oligomerization
response to cAMP
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
definitive hemopoiesis
heart trabecula formation
positive regulation of ERK1 and ERK2 cascade
positive regulation of intracellular signal transduction
positive regulation of actin cytoskeleton reorganization
regulation of endothelial cell apoptotic process
negative regulation of endothelial cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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