Proteintech

TELO2 Polyclonal Antibody

TELO2 Antibody in Immunocytochemistry (ICC/IF)

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TELO2 Antibody (15975-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 15975-1-AP (TELO2 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

TELO2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TELO2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15975-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 13 publications 13 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TELO2 Fusion Protein Ag8763 (488-837 aa encoded by BC017188)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DLDSDDEFV PYDMSGDREL KSSKAPAYVR DCVEALTTSE DIERWEAALR ALEGLVYRSP TATREVSVEL AKVLLHLEEK TCVVGFAGLR QRALVAVTVT DPAPVADYLT SQFYALNYSL RQRMDILDVL TLAAQELSRP GCLGRTPQPG SPSPNTPCLP EAAVSQPGSA VASDWRVVVE ERIRSKTQRL SKGGPRQGPA GSPSRFNSVA GHFFFPLLQR FDRPLVTFDL LGEDQLVLGR LAHTLGALMC LAVNTTVAVA MGKALLEFVW ALRFHIDAYV RQGLLSAVSS VLLSLPAARL LEDLMDELLE ARSWLADVAE KDPDEDCRTL ALRALLLLQR LKNRLLPPAS P (488-837 aa encoded by BC017188)

Target Information

TELO2 is a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Bi-allelic TTI1 variants cause an autosomal-recessive neurodevelopmental disorder with microcephaly.

American journal of human genetics

Serey-Gaut M,Cortes M,Makrythanasis P,Suri M,Taylor AMR,Sullivan JA,Asleh AN,Mitra J,Dar MA,McNamara A,Shashi V,Dugan S,Song X,Rosenfeld JA,Cabrol C,Iwaszkiewicz J,Zoete V,Pehlivan D,Akdemir ZC,Roeder ER,Littlejohn RO,Dibra HK,Byrd PJ,Stewart GS,Geckinli BB,Posey J,Westman R,Jungbluth C,Eason J,Sachdev R,Evans CA,Lemire G,VanNoy GE,O'Donnell-Luria A,Mau-Them FT,Juven A,Piard J,Nixon CY,Zhu Y,Ha T,Buckley MF,Thauvin C,Essien Umanah GK,Van Maldergem L,Lupski JR,Roscioli T,Dawson VL,Dawson TM,Antonarakis SE

Thu Mar 02 00:00:00 UTC 2023

Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases.

iScience

Yonezawa H,Ikeda A,Takahashi R,Endo H,Sugawara Y,Goto M,Kanno M,Ogawa S,Nakamura K,Ujiie H,Iwatsuki M,Hirose T,Sunazuka T,Uehara Y,Nishiya N

Fri Mar 18 00:00:00 UTC 2022

Structure of the Human TELO2-TTI1-TTI2 Complex.

Journal of molecular biology

Kim Y,Park J,Joo SY,Kim BG,Jo A,Lee H,Cho Y

Sun Jan 30 00:00:00 UTC 2022

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.

Molecular cell

Heider M,Eichner R,Stroh J,Morath V,Kuisl A,Zecha J,Lawatscheck J,Baek K,Garz AK,Rudelius M,Deuschle FC,Keller U,Lemeer S,Verbeek M,Götze KS,Skerra A,Weber WA,Buchner J,Schulman BA,Kuster B,Fernández-Sáiz V,Bassermann F

Thu Mar 18 00:00:00 UTC 2021

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.

Cell chemical biology

Yenerall P,Das AK,Wang S,Kollipara RK,Li LS,Villalobos P,Flaming J,Lin YF,Huffman K,Timmons BC,Gilbreath C,Sonavane R,Kinch LN,Rodriguez-Canales J,Moran C,Behrens C,Hirasawa M,Takata T,Murakami R,Iwanaga K,Chen BPC,Grishin NV,Raj GV,Wistuba II,Minna JD,Kittler R

Thu Jan 16 00:00:00 UTC 2020

Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells.

Science advances

Shin SH,Lee JS,Zhang JM,Choi S,Boskovic ZV,Zhao R,Song M,Wang R,Tian J,Lee MH,Kim JH,Jeong M,Lee JH,Petukhov M,Lee SW,Kim SG,Zou L,Byun S

Wed Jul 01 00:00:00 UTC 2020

The effects of Tel2 on cardiomyocyte survival.

Life sciences

Yorichika N,Baba Y,Shimada BK,Thakore M,Wong SM,Kobayashi M,Higa JK,Matsui T

Sun Sep 01 00:00:00 UTC 2019

MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.

Cell reports

Brown MC,Gromeier M

Tue Feb 07 00:00:00 UTC 2017

MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.

Cell reports

Brown MC,Gromeier M

Tue Feb 07 00:00:00 UTC 2017

A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.

Genes & development

Wang Y,Xu Q,Sack L,Kang C,Elledge SJ

Mon Feb 01 00:00:00 UTC 2016

A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.

Genes & development

Wang Y,Xu Q,Sack L,Kang C,Elledge SJ

Mon Feb 01 00:00:00 UTC 2016

A Syndromic Intellectual Disability Disorder Caused by Variants in TELO2, a Gene Encoding a Component of the TTT Complex.

American journal of human genetics

You J,Sobreira NL,Gable DL,Jurgens J,Grange DK,Belnap N,Siniard A,Szelinger S,Schrauwen I,Richholt RF,Vallee SE,Dinulos MBP,Valle D,Armanios M,Hoover-Fong J

Thu May 05 00:00:00 UTC 2016

A Syndromic Intellectual Disability Disorder Caused by Variants in TELO2, a Gene Encoding a Component of the TTT Complex.

American journal of human genetics

You J,Sobreira NL,Gable DL,Jurgens J,Grange DK,Belnap N,Siniard A,Szelinger S,Schrauwen I,Richholt RF,Vallee SE,Dinulos MBP,Valle D,Armanios M,Hoover-Fong J

Thu May 05 00:00:00 UTC 2016

Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress.

Biochimica et biophysica acta

Baena M,Sangüesa G,Hutter N,Sánchez RM,Roglans N,Laguna JC,Alegret M

Sun Feb 01 00:00:00 UTC 2015

Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress.

Biochimica et biophysica acta

Baena M,Sangüesa G,Hutter N,Sánchez RM,Roglans N,Laguna JC,Alegret M

Sun Feb 01 00:00:00 UTC 2015

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.

Nature cell biology

Fernández-Sáiz V,Targosz BS,Lemeer S,Eichner R,Langer C,Bullinger L,Reiter C,Slotta-Huspenina J,Schroeder S,Knorn AM,Kurutz J,Peschel C,Pagano M,Kuster B,Bassermann F

Tue Jan 01 00:00:00 UTC 2013

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.

Nature cell biology

Fernández-Sáiz V,Targosz BS,Lemeer S,Eichner R,Langer C,Bullinger L,Reiter C,Slotta-Huspenina J,Schroeder S,Knorn AM,Kurutz J,Peschel C,Pagano M,Kuster B,Bassermann F

Tue Jan 01 00:00:00 UTC 2013

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

Molecular cell

Kim SG,Hoffman GR,Poulogiannis G,Buel GR,Jang YJ,Lee KW,Kim BY,Erikson RL,Cantley LC,Choo AY,Blenis J

Thu Jan 10 00:00:00 UTC 2013

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

Molecular cell

Kim SG,Hoffman GR,Poulogiannis G,Buel GR,Jang YJ,Lee KW,Kim BY,Erikson RL,Cantley LC,Choo AY,Blenis J

Thu Jan 10 00:00:00 UTC 2013

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

Genes & development

Hurov KE,Cotta-Ramusino C,Elledge SJ

Wed Sep 01 00:00:00 UTC 2010

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

Genes & development

Hurov KE,Cotta-Ramusino C,Elledge SJ

Wed Sep 01 00:00:00 UTC 2010

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

Genes & development

Hurov KE,Cotta-Ramusino C,Elledge SJ

Wed Sep 01 00:00:00 UTC 2010

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

Genes & development

Hurov KE,Cotta-Ramusino C,Elledge SJ

Wed Sep 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: hCLK2; Protein clk-2 homolog; TEL2, telomere maintenance 2, homolog; Telomere length regulation protein TEL2 homolog

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Gene Aliases: CLK2; KIAA0683; TEL2; TELO2; YHFS

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UniProt ID: (Human) Q9Y4R8

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Entrez Gene ID: (Human) 9894

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Function(s)

protein binding protein kinase binding protein complex binding protein complex scaffold Hsp90 protein binding

Process(es)

regulation of TOR signaling protein stabilization positive regulation of protein serine/threonine kinase activity positive regulation of TORC1 signaling positive regulation of TORC2 signaling

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TELO2 Polyclonal Antibody

TELO2 Antibody (15975-1-AP) in ICC/IF

Product Details

15975-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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