Proteintech

TFAP2B Polyclonal Antibody

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View all (11) AP2 beta antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

13183-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TFAP2B Fusion Protein Ag3853 (111-460 aa encoded by BC037225)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RQEVGSEAG SLLPQPRAAL PQLSGLDPRR DYHSVRRPDV LLHSAHHGLD AGMGDSLSLH GLGHPGMEDV QSVEDANNSG MNLLDQSVIK KVPVPPKSVT SLMMNKDGFL GGMSVNTGEV FCSVPGRLSL LSSTSKYKVT VGEVQRRLSP PECLNASLLG GVLRRAKSKN GGRSLRERLE KIGLNLPAGR RKAANVTLLT SLVEGEAVHL ARDFGYICET EFPAKAVSEY LNRQHTDPSD LHSRKNMLLA TKQLCKEFTD LLAQDRTPIG NSRPSPILEP GIQSCLTHFS LITHGFGAPA ICAALTALQN YLTEALKGMD KMFLNNTTTN RHTSGEGPGS KTGDKEEKHR K (111-460 aa encoded by BC037225)

Target Information

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: activating enhancer binding protein 2 beta; activating enhancer-binding protein 2 beta; Activating enhancer-binding protein 2-beta; AP2-beta; transcription factor AP-2 beta (activating enhancer binding protein 2 beta); Transcription factor AP-2-beta

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Gene Aliases: AI606113; AP-2(beta); AP-2B; AP2-B; E130018K07Rik; Tcfap2b; TFAP2B

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UniProt ID: (Human) Q92481, (Mouse) Q61313

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Entrez Gene ID: (Human) 7021, (Mouse) 21419, (Rat) 301285

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Function(s)
RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator activity RNA polymerase II transcription corepressor activity enhancer sequence-specific DNA binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity transcription corepressor activity protein binding protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process sequence-specific DNA binding protein heterodimerization activity protein dimerization activity RNA polymerase II regulatory region sequence-specific DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter kidney development renal water homeostasis glucose metabolic process regulation of transcription, DNA-templated transcription from RNA polymerase II promoter apoptotic process positive regulation of cell proliferation negative regulation of cell proliferation response to lithium ion retina layer formation magnesium ion homeostasis regulation of BMP signaling pathway forelimb morphogenesis hindlimb morphogenesis positive regulation of urine volume aorta morphogenesis response to drug glucose homeostasis negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process skin development fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development regulation of insulin secretion phosphate ion homeostasis calcium ion homeostasis potassium ion homeostasis sodium ion homeostasis distal tubule development collecting duct development metanephric nephron development ductus arteriosus closure cellular ammonia homeostasis cellular creatinine homeostasis cellular urea homeostasis transcription, DNA-templated regulation of transcription from RNA polymerase II promoter regulation of cell proliferation anatomical structure development
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