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Product Details
13547-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TFEC Fusion Protein Ag4061 (1-197 aa encoded by BC029891)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTLDHQIIN PTLKWSQPAV PSGGPLVQHA HTTLDSDAGL TENPLTKLLA IGKEDDNAQW HLSGSILDVY SGEQGISPIN MGLTSASCPS SLPMKREITE TDTRALAKER QKKDNHNLIE RRRRYNINYR IKELGTLIPK SNDPDMRWNK GTILKASVEY IKWLQKEQQR ARELEHRQKK LEQANRRLLL RIQVFIRM (1-197 aa encoded by BC029891)
Target Information
This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHe34; Class E basic helix-loop-helix protein 34; hTFEC-L; mTFEC; rTFEC; TFE-C; Transcription factor EC; Transcription factor EC-like
Gene Aliases: BB107417; BHLHE34; hTFEC-L; TCFEC; TFE-C; TFEC; TFEC-L; TFECL
UniProt ID: (Human) O14948, (Rat) Q63302, (Mouse) Q9WTW4
Entrez Gene ID: (Human) 22797, (Rat) 26296, (Mouse) 21426
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
protein dimerization activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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