Proteintech

TFF2 Polyclonal Antibody

TFF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TFF2 Antibody (13681-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human stomach tissue slide using 13681-1-AP ( TFF2 Antibody) at dilution of 1:1000 (under 40x lens).

TFF2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13681-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 22 publications 22 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 16 publications 16 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Gerbil, Human, Mouse, Rodent

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TFF2 Fusion Protein Ag4537 (1-129 aa encoded by BC032820)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGRRDAQLL AALLVLGLCA LAGSEKPSPC QCSRLSPHNR TNCGFPGITS DQCFDNGCCF DSSVTGVPWC FHPLPKQESD QCVMEVSDRR NCGYPGISPE ECASRKCCFS NFIFEVPWCF FPKSVEDCHY (1-129 aa encoded by BC032820)

Target Information

Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, is a trefoil protein that functions to inhibit gastrointestinal motility and gastric acid secretion. SP may also act as a structural component of the gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Fri Jul 01 00:00:00 UTC 2022

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Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy.

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Tue Feb 01 00:00:00 UTC 2022

Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.

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