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Invitrogen
TFR2 Polyclonal Antibody
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TFR2 Antibody (PA5-29137) in IHC (P)
TFR2 Polyclonal Antibody detects TFR2 protein at cytosol on human hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded hepatoma. TFR2 Polyclonal Antibody (Product # PA5-29137) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-29137
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Extracellular domain of human TFR2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2546613
Product Specific Information
Recommended positive controls: K562, HL-60.
Predicted reactivity: Mouse (89%), Rat (88%), Bovine (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC126368; TfR2; Transferrin receptor protein 2
Gene Aliases: HFE3; TFR2; TFRC2
UniProt ID: (Human) Q9UP52
Entrez Gene ID: (Human) 7036
iron ion transport
cellular iron ion homeostasis
receptor-mediated endocytosis
response to iron ion
transferrin transport
positive regulation of endocytosis
positive regulation of transcription from RNA polymerase II promoter
iron ion homeostasis
cellular response to iron ion
positive regulation of peptide hormone secretion
ferrous iron import into cell
positive regulation of protein maturation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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