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Invitrogen
TGF beta-1 Polyclonal Antibody
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TGF beta-1 Antibody (PA5-143476) in WB
Western blot analysis of TGF beta-1 in zebrafish tissue extract (30 µg) separated by 10% SDS-PAGE. Membrane was blotted with TGF beta-1 Polyclonal antibody (Product # PA5-143476) using a dilution of 1:1,000 followed by HRP-conjugated anti-rabbit IgG secondary antibody.
Product Details
PA5-143476
Product Specifications
Species Reactivity
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of zebrafish Tgfb1a. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.86 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2938471
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: TGF b; TGF b 1; TGF beta; tgf beta 1; TGF beta-1; TGF beta-1 protein; tgf beta1; TGF β; TGF β 1; TGF β1; TGF-B1; TGF-beta 1 protein; TGFβ1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor β1; transforming growth factor, beta 1
Gene Aliases: ai39657; tgfb1; wu:fb13a07; xx:ai39657
Entrez Gene ID: (Zebrafish) 359834
transforming growth factor beta receptor signaling pathway
positive regulation of pathway-restricted SMAD protein phosphorylation
posterior lateral line neuromast hair cell development
regulation of cell proliferation
regulation of apoptotic process
regulation of MAPK cascade
cell development
otolith development
posterior lateral line neuromast development
posterior lateral line neuromast primordium migration
posterior lateral line neuromast deposition
positive regulation of cell division
hematopoietic stem cell differentiation
SMAD protein signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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