Exalpha

TGF beta II receptor (27-85) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

L110P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100
-

Immunohistochemistry (IHC)

Assay-dependent
-
Product Specifications

Species Reactivity

Chicken

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A recombinant protein containing chick transforming growth factor type II receptor a.a.27-85
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-2 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

PBS

Contains

0.08% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: Recombinant proteins conjugated to OVA, GST, His tags and other. Native TGF beta II proteins.

Target Information

Transforming Growth Factor, beta receptor 2 (AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII) is a member of the TGF-beta family of receptor Serine/Threonine kinases. It is involved in the regulation of cell proliferation. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). TGFBR2 encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. TGFBR2 also has a pseudogene on chromosome 14.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: tbetaR-II; tgf beta receptor 2; TGF-beta receptor type II; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta RII; TGFR-2; TGFR2; Transforming growth factor-beta receptor type II; transforming growth factor-beta type II receptor

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Gene Aliases: TGFBR2

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UniProt ID: (Chicken) Q90999

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Entrez Gene ID: (Chicken) 396399

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Function(s)
receptor signaling protein serine/threonine kinase activity transforming growth factor beta receptor activity, type II protein binding ATP binding type I transforming growth factor beta receptor binding SMAD binding metal ion binding transforming growth factor beta binding
Process(es)
patterning of blood vessels vasculogenesis eye development in utero embryonic development cell activation positive regulation of mesenchymal cell proliferation lens development in camera-type eye positive regulation of tolerance induction to self antigen positive regulation of B cell tolerance induction positive regulation of T cell tolerance induction negative regulation of cell adhesion transforming growth factor beta receptor signaling pathway smoothened signaling pathway gastrulation brain development heart development embryo development regulation of gene expression positive regulation of epithelial cell migration positive regulation of epithelial to mesenchymal transition cell migration negative regulation of cell-cell adhesion lung development positive regulation of cell migration activation of protein kinase activity embryonic hemopoiesis regulation of growth myeloid dendritic cell differentiation embryonic cranial skeleton morphogenesis mesenchymal cell differentiation positive regulation of NK T cell differentiation cartilage development palate development cardiac epithelial to mesenchymal transition bronchus morphogenesis trachea formation mammary gland morphogenesis lung lobe morphogenesis response to cholesterol lens fiber cell apoptotic process
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