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          • Primary Antibodies ›
          • TGFBR1 Antibodies

          Bioss

          TGF beta Receptor 1 Polyclonal Antibody

          View all (21) TGFBR1 antibodies

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          Cite TGF beta Receptor 1 Polyclonal Antibody

          • Antibody Testing Data (2)
          TGF beta Receptor 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          TGF beta Receptor 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          FIGURE: 1 / 2

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          TGF beta Receptor 1 Antibody (BS-0638R) in IHC (P)

          Formalin-fixed and paraffin embedded rat brain tissue labeled Anti-TGF Beta R1/TGFBR1 Polyclonal Antibody, Unconjugated (bs-0638R) at 1:200, followed by conjugation to the secondary antibody and DAB staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          TGF beta Receptor 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TGF beta Receptor 1 Antibody in Western Blot (WB)

          Product Details

          BS-0638R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:200
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:100
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Bovine, Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human TGF-beta R1, amino acids 301-400.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: activin A receptor type II-like kinase, 53kDa; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ESK2; mutant transforming growth factor beta receptor I; ser; Serine/threonine-protein kinase receptor R4; SKR4; tbetaR-I; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; TGFR1; Transfor; transforming growth factor beta receptor I; transforming growth factor beta, receptor 1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa); Transforming growth factor-beta receptor type I

          View more View less

          Gene Aliases: AAT5; ACVRLK4; ALK-5; ALK5; AU017191; BOS_9013; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TbetaR-I; TbetaRI; TGFBR1; TGFR-1

          View more View less

          UniProt ID: (Bovine) O46680, (Human) P36897, (Rat) P80204, (Mouse) Q64729

          View more View less

          Entrez Gene ID: (Bovine) 282382, (Human) 7046, (Rat) 29591, (Mouse) 21812

          View more View less

          Function(s)
          transforming growth factor beta receptor activity, type I type II transforming growth factor beta receptor binding ATP binding metal ion binding transforming growth factor beta binding I-SMAD binding protein kinase activity protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity receptor signaling protein activity protein binding growth factor binding SMAD binding ubiquitin protein ligase binding protein complex binding protein heterodimerization activity nucleotide binding transmembrane receptor protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
          Process(es)
          activation of MAPKK activity angiogenesis kidney development blastocyst development epithelial to mesenchymal transition negative regulation of endothelial cell proliferation lens development in camera-type eye apoptotic process transforming growth factor beta receptor signaling pathway heart development positive regulation of cell proliferation germ cell migration post-embryonic development anterior/posterior pattern specification positive regulation of pathway-restricted SMAD protein phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation collagen fibril organization positive regulation of cell growth regulation of protein ubiquitination negative regulation of chondrocyte differentiation negative regulation of apoptotic process regulation of protein binding endothelial cell migration positive regulation of transcription, DNA-templated thymus development neuron fate commitment embryonic cranial skeleton morphogenesis artery morphogenesis positive regulation of cellular component movement positive regulation of filopodium assembly positive regulation of protein kinase B signaling parathyroid gland development palate development pharyngeal system development pathway-restricted SMAD protein phosphorylation positive regulation of SMAD protein import into nucleus response to cholesterol cellular response to transforming growth factor beta stimulus skeletal system development response to hypoxia in utero embryonic development positive regulation of endothelial cell proliferation regulation of transcription, DNA-templated protein phosphorylation signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway embryo implantation aging male gonad development response to toxic substance regulation of gene expression positive regulation of gene expression regulation of epithelial to mesenchymal transition response to organic cyclic compound signal transduction by protein phosphorylation lung development organ regeneration activin receptor signaling pathway response to prostaglandin E intracellular signal transduction regulation of growth endothelial cell activation response to estrogen negative regulation of endothelial cell differentiation protein autophosphorylation digestive tract development skeletal system morphogenesis mesenchymal cell differentiation cell motility response to electrical stimulus cardiac epithelial to mesenchymal transition positive regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis proepicardium development cell cycle arrest positive regulation of epithelial to mesenchymal transition positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway wound healing extracellular structure organization positive regulation of stress fiber assembly regulation of cardiac muscle cell proliferation ventricular septum morphogenesis coronary artery morphogenesis positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of occluding junction disassembly embryo development phosphorylation cell differentiation
          It has to be done as per old AB suggested Products section.
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