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          • Primary Antibodies ›
          • TGFBR1 Antibodies

          Invitrogen

          TGFBR1 Polyclonal Antibody

          View all (21) TGFBR1 antibodies

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          Cite TGFBR1 Polyclonal Antibody

          • Antibody Testing Data (1)
          TGFBR1 Antibody in Western Blot (WB)
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          TGFBR1 Antibody in Western Blot (WB)
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          TGFBR1 Antibody (PA5-95387) in WB

          Western blot analysis of TGFBR1 in rat cardiac muscle extract (lane 1), mouse liver extract (lane 2) and HeLa whole cell lysates (lane 3). Samples were incubated with TGFBR1 polyclonal antibody (Product # PA5-95387) using a 0.5 µg/mL dilution. developed was performed using enhanced chemiluminescence (ECL). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          TGFBR1 Antibody in Western Blot (WB)

          Product Details

          PA5-95387

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          0.1-0.5 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthetic peptide corresponding to a sequence at the N-terminus of human TGFBR1 (149-186aa HNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTT).
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Lyophilized

          Concentration

          500 µg/mL

          Purification

          Affinity chromatography

          Storage buffer

          PBS with 4mg trehalose

          Contains

          no preservative

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2807190

          Product Specific Information

          Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

          Positive Control - WB: rat cardiac muscle tissue, mouse liver tissue, HELA whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

          Target Information

          TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: activin A receptor type II-like kinase, 53kDa; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ESK2; mutant transforming growth factor beta receptor I; ser; Serine/threonine-protein kinase receptor R4; SKR4; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; TGFR1; Transfor; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I; Transforming growth factor-beta receptor type I

          View more View less

          Gene Aliases: AAT5; ACVRLK4; ALK-5; ALK5; AU017191; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TbetaR-I; TbetaRI; TGFBR1; TGFR-1

          View more View less

          UniProt ID: (Human) P36897, (Rat) P80204, (Mouse) Q64729

          View more View less

          Entrez Gene ID: (Human) 7046, (Rat) 29591, (Mouse) 21812

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          Function(s)
          protein kinase activity protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I receptor signaling protein activity type II transforming growth factor beta receptor binding protein binding ATP binding growth factor binding SMAD binding metal ion binding transforming growth factor beta binding I-SMAD binding ubiquitin protein ligase binding protein complex binding protein heterodimerization activity nucleotide binding transmembrane receptor protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
          Process(es)
          activation of MAPKK activity skeletal system development angiogenesis response to hypoxia in utero embryonic development kidney development blastocyst development epithelial to mesenchymal transition negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lens development in camera-type eye regulation of transcription, DNA-templated protein phosphorylation apoptotic process signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway heart development embryo implantation aging positive regulation of cell proliferation germ cell migration male gonad development response to toxic substance post-embryonic development anterior/posterior pattern specification regulation of gene expression positive regulation of gene expression regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation response to organic cyclic compound peptidyl-serine phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation collagen fibril organization positive regulation of cell growth lung development organ regeneration regulation of protein ubiquitination negative regulation of chondrocyte differentiation activin receptor signaling pathway response to prostaglandin E intracellular signal transduction regulation of growth endothelial cell activation negative regulation of apoptotic process regulation of protein binding endothelial cell migration response to estrogen negative regulation of endothelial cell differentiation positive regulation of transcription, DNA-templated protein autophosphorylation thymus development digestive tract development neuron fate commitment embryonic cranial skeleton morphogenesis skeletal system morphogenesis mesenchymal cell differentiation artery morphogenesis cell motility positive regulation of cellular component movement positive regulation of filopodium assembly response to electrical stimulus positive regulation of protein kinase B signaling parathyroid gland development palate development pharyngeal system development cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation positive regulation of SMAD protein import into nucleus response to cholesterol cellular response to transforming growth factor beta stimulus positive regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis proepicardium development cell cycle arrest positive regulation of epithelial to mesenchymal transition positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway wound healing extracellular structure organization positive regulation of stress fiber assembly regulation of cardiac muscle cell proliferation ventricular septum morphogenesis coronary artery morphogenesis positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of occluding junction disassembly embryo development phosphorylation cell differentiation
          It has to be done as per old AB suggested Products section.
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