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Invitrogen
TGFBR3 Monoclonal Antibody (1C5H11)
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Product Details
MA5-17187
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C5H11
Immunogen
Purified recombinant fragment of human TGFBR3 (amino acids: 147-328 ) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2538658
Product Specific Information
MA5-17187 targets TGFBR3 in indirect ELISA, WB applications and shows reactivity with Human and Mouse samples.
The MA5-17187 immunogen is purified recombinant fragment of human TGFBR3 (amino acids: 147-328 ) expressed in E. Coli.
MA5-17187 detects TGFBR3 which has a predicted molecular weight of approximately 93.4kDa.
Target Information
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Betaglycan; betaglycan proteoglycan; OTTHUMP00000011787; tgf beta receptor 3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3
Gene Aliases: 1110036H20Rik; AU015626; AW215636; betaglycan; BGCAN; TBRIII; TGFBR3
UniProt ID: (Human) Q03167, (Mouse) O88393
Entrez Gene ID: (Human) 7049, (Mouse) 21814
transforming growth factor beta-activated receptor activity
type II transforming growth factor beta receptor binding
transforming growth factor beta receptor binding
protein binding
glycosaminoglycan binding
heparin binding
coreceptor activity
fibroblast growth factor binding
PDZ domain binding
SMAD binding
activin binding
transforming growth factor beta binding
transforming growth factor beta receptor activity, type III
blood vessel development
vasculogenesis
osteoblast differentiation
in utero embryonic development
blastocyst development
epithelial to mesenchymal transition
liver development
blood vessel remodeling
epicardial cell to mesenchymal cell transition
protein complex assembly
protein phosphorylation
immune response
transforming growth factor beta receptor signaling pathway
transforming growth factor beta receptor complex assembly
positive regulation of cell proliferation
embryo development
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
cell growth
BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
response to follicle-stimulating hormone
response to prostaglandin E
response to luteinizing hormone
intracellular signal transduction
regulation of protein binding
negative regulation of epithelial cell proliferation
regulation of blood vessel size
positive regulation of NF-kappaB transcription factor activity
negative regulation of cellular component movement
ventricular cardiac muscle tissue morphogenesis
palate development
cardiac muscle cell proliferation
definitive hemopoiesis
cardiac epithelial to mesenchymal transition
definitive erythrocyte differentiation
heart trabecula formation
pathway-restricted SMAD protein phosphorylation
coronary vasculature development
coronary vasculature morphogenesis
vasculogenesis involved in coronary vascular morphogenesis
visceral serous pericardium development
negative regulation of apoptotic process involved in morphogenesis
response to hypoxia
heart morphogenesis
cell migration
organ regeneration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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