Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Exalpha
TGFbeta receptor III Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
X1484P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein derived from the extracellular domain of the chicken TGF III receptor protein. Protein shares significant homology with the mouse, rat and human sequences.
Conjugate
Form
Liquid
Concentration
0.5-2 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Extraembryonic membranes from chick embryos.
Target Information
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: FLJ16571; H-TGF-b-3; tgf beta 3; TGF-beta-3; Transforming growth factor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor-beta3
Gene Aliases: TGF-beta3; TGFB3
UniProt ID: (Chicken) P16047
Entrez Gene ID: (Chicken) 396438
cell activation
epithelial to mesenchymal transition involved in endocardial cushion formation
negative regulation of cell adhesion
nervous system development
cell growth
positive regulation of cell migration
positive regulation of transcription, DNA-templated
spleen development
embryonic digestive tract development
positive regulation of cell division
cardiac epithelial to mesenchymal transition
mesenchyme migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support