Proteintech

TGM1 Polyclonal Antibody

TGM1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TGM1 Antibody (12912-3-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using 12912-3-AP (TGM1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

TGM1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12912-3-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:600

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TGM1 Fusion Protein Ag3905 (467-817 aa encoded by BC034699)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody recognizes the endogenous 90 kDa TGM1 proteins.

Immunogen sequence: SGIFCCGPC SVESIKNGLV YMKYDTPFIF AEVNSDKVYW QRQDDGSFKI VYVEEKAIGT LIVTKAISSN MREDITYLYK HPEGSDAERK AVETAAAHGS KPNVYANRGS AEDVAMQVEA QDAVMGQDLM VSVMLINHSS SRRTVKLHLY LSVTFYTGVS GTIFKETKKE VELAPGASDR VTMPVAYKEY RPHLVDQGAM LLNVSGHVKE SGQVLAKQHT FRLRTPDLSL TLLGAAVVGQ ECEVQIVFKN PLPVTLTNVV FRLEGSGLQR PKILNVGDIG GNETVTLRQS FVPVRPGPRQ LIASLDSPQL SQVHGVIQVD VAPAPGDGGF FSDAGGDSHL GETIPMASRG GA (467-817 aa encoded by BC034699)

Target Information

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Cathelicidin LL-37 Activates Human Keratinocyte Autophagy through the P2X₇, Mechanistic Target of Rapamycin, and MAPK Pathways.

The Journal of investigative dermatology

Ikutama R,Peng G,Tsukamoto S,Umehara Y,Trujillo-Paez JV,Yue H,Nguyen HLT,Takahashi M,Kageyama S,Komatsu M,Okumura K,Ogawa H,Ikeda S,Niyonsaba F

Mon May 01 00:00:00 UTC 2023

A Newly Developed Chemically Defined Serum-Free Medium Suitable for Human Primary Keratinocyte Culture and Tissue Engineering Applications.

International journal of molecular sciences

Ghio SC,Barbier MA,Doucet EJ,Debbah I,Safoine M,Le-Bel G,Cartier A,Jolibois E,Morissette A,Larouche D,Fradette J,Guérin SL,Garnier A,Germain L

Tue Jan 17 00:00:00 UTC 2023

Targeting Multiple Hallmarks of Skin Aging: Preclinical and Clinical Efficacy of a Novel Growth Factor-Based Skin Care Serum.

Dermatology and therapy

Naughton GK,Jiang LI,Makino ET,Chung R,Nguyen A,Cheng T,Kadoya K,Mehta RC

Sun Jan 01 00:00:00 UTC 2023

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis.

Biomedicines

Igarashi T,Yanagi H,Yagi M,Ichihashi M,Imokawa G

Mon Feb 13 00:00:00 UTC 2023

Divergent transcriptional regulation of astrocyte reactivity across disorders.

Nature

Burda JE,O'Shea TM,Ao Y,Suresh KB,Wang S,Bernstein AM,Chandra A,Deverasetty S,Kawaguchi R,Kim JH,McCallum S,Rogers A,Wahane S,Sofroniew MV

Wed Jun 01 00:00:00 UTC 2022

Inhibiting Hyper-O-GlcNAcylation of c-Myc accelerate diabetic wound healing by alleviating keratinocyte dysfunction.

Burns & trauma

Zhang J,Yang P,Liu D,Gao M,Wang J,Yu T,Zhang X,Liu Y

Wed Apr 27 00:00:00 UTC 2022

Inhibiting Hyper-O-GlcNAcylation of c-Myc accelerate diabetic wound healing by alleviating keratinocyte dysfunction.

Burns & trauma

Zhang J,Yang P,Liu D,Gao M,Wang J,Yu T,Zhang X,Liu Y

Wed Apr 27 00:00:00 UTC 2022

Inhibiting Hyper-O-GlcNAcylation of c-Myc accelerate diabetic wound healing by alleviating keratinocyte dysfunction.

Burns & trauma

Zhang J,Yang P,Liu D,Gao M,Wang J,Yu T,Zhang X,Liu Y

Wed Apr 27 00:00:00 UTC 2022

Inhibiting Hyper-O-GlcNAcylation of c-Myc accelerate diabetic wound healing by alleviating keratinocyte dysfunction.

Burns & trauma

Zhang J,Yang P,Liu D,Gao M,Wang J,Yu T,Zhang X,Liu Y

Wed Apr 27 00:00:00 UTC 2022

Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium.

European journal of oral sciences

Roy RR,Shimada K,Murakami S,Hasegawa H

Mon Feb 01 00:00:00 UTC 2021

Enhancement of Cornified Envelope-Related Gene and Protein Expression by Carba Cyclic Phosphatidic Acid in Normal Human Epidermal Keratinocytes.

Biological & pharmaceutical bulletin

Saito E,Kage M,Tokudome Y

Thu Oct 14 00:00:00 UTC 2021

Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells.

The Journal of investigative dermatology

Simard M,Rioux G,Morin S,Martin C,Guérin SL,Flamand N,Julien P,Fradette J,Pouliot R

Fri Oct 01 00:00:00 UTC 2021

Docosahexaenoic Acid Modulates Paracellular Absorption of Testosterone and Claudin-1 Expression in a Tissue-Engineered Skin Model.

International journal of molecular sciences

Tremblay A,Simard M,Morin S,Pouliot R

Fri Dec 03 00:00:00 UTC 2021

Effect of Lactic Fermentation Products on Human Epidermal Cell Differentiation, Ceramide Content, and Amino Acid Production.

Skin pharmacology and physiology

Otsuka M,Tamane T,Tokudome Y

Mon Nov 15 00:00:00 UTC 2021

c-Myc Upregulated by High Glucose Inhibits HaCaT Differentiation by S100A6 Transcriptional Activation.

Frontiers in endocrinology

Zhang J,Yang P,Liu D,Gao M,Wang J,Wang X,Liu Y,Zhang X

Wed Dec 22 00:00:00 UTC 2021

Restoration of calcium-induced differentiation potential and tight junction formation in HaCaT keratinocytes by functional attenuation of overexpressed high mobility group box-1 protein.

Cytotechnology

Tanaka F,Uda M,Hirose Y,Hirai Y

Sat Feb 01 00:00:00 UTC 2020

Specialized Living Wound Dressing Based on the Self-Assembly Approach of Tissue Engineering.

Journal of functional biomaterials

Cantin-Warren L,Guignard R,Cortez Ghio S,Larouche D,Auger FA,Germain L

Sat Sep 15 00:00:00 UTC 2018

Specialized Living Wound Dressing Based on the Self-Assembly Approach of Tissue Engineering.

Journal of functional biomaterials

Cantin-Warren L,Guignard R,Cortez Ghio S,Larouche D,Auger FA,Germain L

Sat Sep 15 00:00:00 UTC 2018

Characterization of Epidermal Lipoxygenase Expression in Normal Human Skin and Tissue-Engineered Skin Substitutes.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Simard-Bisson C,Parent LA,Moulin VJ,Fruteau de Laclos B

Thu Nov 01 00:00:00 UTC 2018

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

Dang NN,Pang SG,Song HY,An LG,Ma XL

Thu Jan 01 00:00:00 UTC 2015

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

Dang NN,Pang SG,Song HY,An LG,Ma XL

Thu Jan 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Epidermal TGase; K polypeptide; K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase; Protein-glutamine gamma-glutamyltransferase K; protein-glutamine-gamma-glutamyltransferase; TG K; TG(K); TGase 1; TGase K; TGase-1; TGK; transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); transglutaminase 1 isoform; transglutaminase 1, K polypeptide; Transglutaminase K; transglutaminase type 1; transglutaminase, keratinocyte; Transglutaminase-1

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Gene Aliases: 2310004J08Rik; ARCI1; ICR2; KTG; LI; LI1; TGASE; Tgase1; TGK; TGM1

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UniProt ID: (Human) P22735, (Rat) P23606, (Mouse) Q9JLF6

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Entrez Gene ID: (Human) 7051, (Rat) 60335, (Mouse) 21816

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Function(s)

protein-glutamine gamma-glutamyltransferase activity protein binding metal ion binding transferase activity transferase activity, transferring acyl groups

Process(es)

organ morphogenesis peptide cross-linking keratinocyte differentiation keratinization protein metabolic process cellular protein modification process positive regulation of keratinocyte proliferation cell envelope organization positive regulation of cell cycle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TGM1 Polyclonal Antibody

TGM1 Antibody (12912-3-AP) in IHC (P)

Product Details

12912-3-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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