Proteintech

TH1L Polyclonal Antibody

FIGURE: 1 / 1

TH1L Antibody (11226-1-AP) in WB

A549 cells were subjected to SDS PAGE followed by western blot with 11226-1-AP (TH1L antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Product Details

11226-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 1 publication 1 publication

Immunoprecipitation (IP)

Assay-dependent

View 1 publication 1 publication

ChIP assay (ChIP)

Assay-dependent

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TH1L Fusion Protein Ag1750 (242-590 aa encoded by BC014952)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QAMMSVLAQ EEQGGSAVRR IAQEVQRFAQ EKGHDASQIT LALGTAASYP RACQALGAML SKGALNPADI TVLFKMFTSM DPPPVELIRV PAFLDLFMQS LFKPGARINQ DHKHKYIHIL AYAASVVETW KKNKRVSINK DELKSTSKAV ETVHNLCCNE NKGASELVAE LSTLYQCIRF PVVAMGVLKW VDWTVSEPRY FQLQTDHTPV HLALLDEIST CHQLLHPQVL QLLVKLFETE HSQLDVMEQL ELKKTLLDRM VHLLSRGYVL PVVSYIRKCL EKLDTDISLI RYFVTEVLDV IAPPYTSDFV QLFLPILEND SIAGTIKTEG EHDPVTEFIA HCKSNFIMVN (242-590 aa encoded by BC014952)

Target Information

The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Strength of T cell signaling regulates HIV-1 replication and establishment of latency.

PLoS pathogens

Gagne M,Michaels D,Schiralli Lester GM,Gummuluru S,Wong WW,Henderson AJ

Wed May 01 00:00:00 UTC 2019

RNAP II processivity is a limiting step for HIV-1 transcription independent of orientation to and activity of endogenous neighboring promoters.

Virology

Kaczmarek Michaels K,Wolschendorf F,Schiralli Lester GM,Natarajan M,Kutsch O,Henderson AJ

Tue Dec 01 00:00:00 UTC 2015

RNAP II processivity is a limiting step for HIV-1 transcription independent of orientation to and activity of endogenous neighboring promoters.

Virology

Kaczmarek Michaels K,Wolschendorf F,Schiralli Lester GM,Natarajan M,Kutsch O,Henderson AJ

Tue Dec 01 00:00:00 UTC 2015

Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription.

The Journal of biological chemistry

Natarajan M,Schiralli Lester GM,Lee C,Missra A,Wasserman GA,Steffen M,Gilmour DS,Henderson AJ

Fri Sep 06 00:00:00 UTC 2013

Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription.

The Journal of biological chemistry

Natarajan M,Schiralli Lester GM,Lee C,Missra A,Wasserman GA,Steffen M,Gilmour DS,Henderson AJ

Fri Sep 06 00:00:00 UTC 2013

Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription.

The Journal of biological chemistry

Natarajan M,Schiralli Lester GM,Lee C,Missra A,Wasserman GA,Steffen M,Gilmour DS,Henderson AJ

Fri Sep 06 00:00:00 UTC 2013

Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription.

The Journal of biological chemistry

Natarajan M,Schiralli Lester GM,Lee C,Missra A,Wasserman GA,Steffen M,Gilmour DS,Henderson AJ

Fri Sep 06 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: Negative elongation factor C/D; negative elongation factor complex member C/D,Th1l; Negative elongation factor D; negative elongation factor proteins C and D; NELF-C/D; NELF-D; TH1 drosophila homolog; TH1 homolog; TH1-like homolog; TH1-like protein; trihydrophobin 1; trihydrophobin 1 homolog

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Gene Aliases: 2410003I03Rik; C77797; HSPC130; NELF-C; NELF-D; NELFCD; NELFD; TH1; TH1L

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UniProt ID: (Human) Q8IXH7, (Mouse) Q922L6

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Entrez Gene ID: (Human) 51497, (Rat) 679203, (Mouse) 57314

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Function(s)

protein binding molecular_function

Process(es)

biological_process negative regulation of transcription, DNA-templated transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter positive regulation of viral transcription transcription, DNA-templated regulation of transcription, DNA-templated

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TH1L Polyclonal Antibody

TH1L Antibody (11226-1-AP) in WB

Product Details

11226-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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