Proteintech

THAP1 Polyclonal Antibody

THAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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THAP1 Antibody (12584-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 12584-1-AP (THAP1 antibody) at dilution of 1:50 (under 40x lens).

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Product Details

12584-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

ChIP assay (ChIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

THAP1 Fusion Protein Ag3285 (1-213 aa encoded by BC021721)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

12584-1-AP is a rabbit polyclonal antibody raised against full-length of human THAP1.

Immunogen sequence: MVQSCSAYG CKNRYDKDKP VSFHKFPLTR PSLCKEWEAA VRRKNFKPTK YSSICSEHFT PDCFKRECNN KLLKENAVPT IFLCTEPHDK KEDLLEPQEQ LPPPPLPPPV SQVDAAIGLL MPPLQTPVNL SVFCDHNYTV EDTMHQRKRI HQLEQQVEKL RKKLKTAQQR CRRQERQLEK LKEVVHFQKE KDDVSERGYV ILPNDYFEIV EVPA (1-213 aa encoded by BC021721)

Target Information

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family.

Brain : a journal of neurology

Cheng F,Zheng W,Barbuti PA,Bonsi P,Liu C,Casadei N,Ponterio G,Meringolo M,Admard J,Dording CM,Yu-Taeger L,Nguyen HP,Grundmann-Hauser K,Ott T,Houlden H,Pisani A,Krüger R,Riess O

Mon Nov 21 00:00:00 UTC 2022

The dystonia gene THAP1 controls DNA double-strand break repair choice.

Molecular cell

Shinoda K,Zong D,Callen E,Wu W,Dumitrache LC,Belinky F,Chari R,Wong N,Ishikawa M,Stanlie A,Multhaupt-Buell T,Sharma N,Ozelius L,Ehrlich M,McKinnon PJ,Nussenzweig A

Thu Jun 17 00:00:00 UTC 2021

The dystonia gene THAP1 controls DNA double-strand break repair choice.

Molecular cell

Shinoda K,Zong D,Callen E,Wu W,Dumitrache LC,Belinky F,Chari R,Wong N,Ishikawa M,Stanlie A,Multhaupt-Buell T,Sharma N,Ozelius L,Ehrlich M,McKinnon PJ,Nussenzweig A

Thu Jun 17 00:00:00 UTC 2021

Unraveling Molecular Mechanisms of THAP1 Missense Mutations in DYT6 Dystonia.

Journal of molecular neuroscience : MN

Cheng F,Walter M,Wassouf Z,Hentrich T,Casadei N,Schulze-Hentrich J,Barbuti P,Krueger R,Riess O,Grundmann-Hauser K,Ott T

Wed Jul 01 00:00:00 UTC 2020

Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia.

Nature genetics

Meyer E,Carss KJ,Rankin J,Nichols JM,Grozeva D,Joseph AP,Mencacci NE,Papandreou A,Ng J,Barral S,Ngoh A,Ben-Pazi H,Willemsen MA,Arkadir D,Barnicoat A,Bergman H,Bhate S,Boys A,Darin N,Foulds N,Gutowski N,Hills A,Houlden H,Hurst JA,Israel Z,Kaminska M,Limousin P,Lumsden D,McKee S,Misra S,Mohammed SS,Nakou V,Nicolai J,Nilsson M,Pall H,Peall KJ,Peters GB,Prabhakar P,Reuter MS,Rump P,Segel R,Sinnema M,Smith M,Turnpenny P,White SM,Wieczorek D,Wiethoff S,Wilson BT,Winter G,Wragg C,Pope S,Heales SJ,Morrogh D,Pittman A,Carr LJ,Perez-Dueñas B,Lin JP,Reis A,Gahl WA,Toro C,Bhatia KP,Wood NW,Kamsteeg EJ,Chong WK,Gissen P,Topf M,Dale RC,Chubb JR,Raymond FL,Kurian MA

Wed Feb 01 00:00:00 UTC 2017

Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia.

Nature genetics

Wed Feb 01 00:00:00 UTC 2017

The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.

Developmental cell

Yellajoshyula D,Liang CC,Pappas SS,Penati S,Yang A,Mecano R,Kumaran R,Jou S,Cookson MR,Dauer WT

Mon Jul 10 00:00:00 UTC 2017

The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.

Developmental cell

Yellajoshyula D,Liang CC,Pappas SS,Penati S,Yang A,Mecano R,Kumaran R,Jou S,Cookson MR,Dauer WT

Mon Jul 10 00:00:00 UTC 2017

Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia.

Human molecular genetics

Ruiz M,Perez-Garcia G,Ortiz-Virumbrales M,Méneret A,Morant A,Kottwitz J,Fuchs T,Bonet J,Gonzalez-Alegre P,Hof PR,Ozelius LJ,Ehrlich ME

Sun Dec 20 00:00:00 UTC 2015

Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia.

Human molecular genetics

Ruiz M,Perez-Garcia G,Ortiz-Virumbrales M,Méneret A,Morant A,Kottwitz J,Fuchs T,Bonet J,Gonzalez-Alegre P,Hof PR,Ozelius LJ,Ehrlich ME

Sun Dec 20 00:00:00 UTC 2015

Stress-induced changes in gene interactions in human cells.

Nucleic acids research

Nayak RR,Bernal WE,Lee JW,Kearns MJ,Cheung VG

Sat Feb 01 00:00:00 UTC 2014

Stress-induced changes in gene interactions in human cells.

Nucleic acids research

Nayak RR,Bernal WE,Lee JW,Kearns MJ,Cheung VG

Sat Feb 01 00:00:00 UTC 2014

Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions.

Acta neuropathologica communications

Ortiz-Virumbrales M,Ruiz M,Hone E,Dolios G,Wang R,Morant A,Kottwitz J,Ozelius LJ,Gandy S,Ehrlich ME

Thu Sep 18 00:00:00 UTC 2014

Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions.

Acta neuropathologica communications

Ortiz-Virumbrales M,Ruiz M,Hone E,Dolios G,Wang R,Morant A,Kottwitz J,Ozelius LJ,Gandy S,Ehrlich ME

Thu Sep 18 00:00:00 UTC 2014

Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions.

Acta neuropathologica communications

Ortiz-Virumbrales M,Ruiz M,Hone E,Dolios G,Wang R,Morant A,Kottwitz J,Ozelius LJ,Gandy S,Ehrlich ME

Thu Sep 18 00:00:00 UTC 2014

Neural expression of the transcription factor THAP1 during development in rat.

Neuroscience

Zhao Y,Xiao J,Gong S,Clara JA,Ledoux MS

Tue Feb 12 00:00:00 UTC 2013

Neural expression of the transcription factor THAP1 during development in rat.

Neuroscience

Zhao Y,Xiao J,Gong S,Clara JA,Ledoux MS

Tue Feb 12 00:00:00 UTC 2013

Neural expression of the transcription factor THAP1 during development in rat.

Neuroscience

Zhao Y,Xiao J,Gong S,Clara JA,Ledoux MS

Tue Feb 12 00:00:00 UTC 2013

Neural expression of the transcription factor THAP1 during development in rat.

Neuroscience

Zhao Y,Xiao J,Gong S,Clara JA,Ledoux MS

Tue Feb 12 00:00:00 UTC 2013

Direct interaction between causative genes of DYT1 and DYT6 primary dystonia.

Annals of neurology

Gavarini S,Cayrol C,Fuchs T,Lyons N,Ehrlich ME,Girard JP,Ozelius LJ

Fri Oct 01 00:00:00 UTC 2010

Direct interaction between causative genes of DYT1 and DYT6 primary dystonia.

Annals of neurology

Gavarini S,Cayrol C,Fuchs T,Lyons N,Ehrlich ME,Girard JP,Ozelius LJ

Fri Oct 01 00:00:00 UTC 2010

The dystonia gene DYT1 is repressed by the transcription factor THAP1 (DYT6).

Annals of neurology

Kaiser FJ,Osmanoric A,Rakovic A,Erogullari A,Uflacker N,Braunholz D,Lohnau T,Orolicki S,Albrecht M,Gillessen-Kaesbach G,Klein C,Lohmann K

Fri Oct 01 00:00:00 UTC 2010

The dystonia gene DYT1 is repressed by the transcription factor THAP1 (DYT6).

Annals of neurology

Kaiser FJ,Osmanoric A,Rakovic A,Erogullari A,Uflacker N,Braunholz D,Lohnau T,Orolicki S,Albrecht M,Gillessen-Kaesbach G,Klein C,Lohmann K

Fri Oct 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: 4833431A01Rik; nuclear proapoptotic factor; THAP domain containing, apoptosis associated protein 1; THAP domain protein 1; THAP domain-containing apoptosis-associated protein 1; THAP domain-containing protein 1

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Gene Aliases: 4833431A01Rik; AW490810; DYT6; THAP1

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UniProt ID: (Human) Q9NVV9, (Mouse) Q8CHW1, (Rat) Q5U208

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Entrez Gene ID: (Human) 55145, (Mouse) 73754, (Rat) 306547

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Function(s)

protein binding zinc ion binding identical protein binding sequence-specific DNA binding nucleic acid binding DNA binding metal ion binding

Process(es)

endothelial cell proliferation transcription, DNA-templated regulation of transcription, DNA-templated cell cycle regulation of mitotic cell cycle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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THAP1 Polyclonal Antibody

THAP1 Antibody (12584-1-AP) in IHC (P)

Product Details

12584-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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