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Invitrogen
THOC5 Polyclonal Antibody
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Product Details
PA5-31643
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human THOC5. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2549116
Product Specific Information
Recommended positive controls: 293T, A431, HeLa.
Predicted reactivity: Human (99%), Mouse (94%), Rat (94%), Chicken (84%), Chimpanzee (100%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. May be involved in the differentiation of granulocytes and adipocytes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fms-interacting protein; fSAP79; Functional spliceosome-associated protein 79; hTREX90; NF2/meningioma region protein pK1.3; Placental protein 39.2; PP39.2; THO complex subunit 5
Gene Aliases: C22orf19; Fmip; fSAP79; KIAA0983; PK1.3; THOC5
UniProt ID: (Human) Q13769
Entrez Gene ID: (Human) 8563
termination of RNA polymerase II transcription
RNA export from nucleus
mRNA export from nucleus
RNA splicing
monocyte differentiation
mRNA 3'-end processing
positive regulation of DNA-templated transcription, elongation
viral mRNA export from host cell nucleus
primitive hemopoiesis
negative regulation of DNA damage checkpoint
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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