Invitrogen

THRA Monoclonal Antibody (1330)

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View all (26) THRA antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA1-4676

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Rat

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1330

Immunogen

Synthetic peptide corresponding to the N-terminal region of human THRA conjugated to KLH
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Protein G

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_561698

Product Specific Information

This antibody is predicted to react with bovine, mouse and non-human primate based on 100% sequence homology.

This antibody is specific for the ~58 kDa human THR-alpha2 protein.

Target Information

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; c-erb-A thyroid hormone receptor; c-erbA-1; C-erbA-alpha; c-erbA-alpha2; c-erbAalpha2; cerbA protein; cerbAalpha; E ERB-T-1; EAR-7; ERBA ALPHA; ERBA related 7; ERBA-related 7; MGC000261; MGC43240; Nuclear receptor subfamily 1 group A member 1; Oncogene ERBA; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; TR; TR alpha 1+2; triiodothyronine receptor; V-erbA-related protein 7

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Gene Aliases: AR7; c-ERBA-1; C-erba-alpha; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; THRA; THRA1; THRA2

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UniProt ID: (Human) P10827, (Rat) P63059

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Entrez Gene ID: (Human) 7067, (Rat) 81812

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Function(s)
transcription regulatory region sequence-specific DNA binding steroid receptor RNA activator RNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity thyroid hormone receptor activity protein binding transcription factor binding zinc ion binding TBP-class protein binding protein domain specific binding chromatin DNA binding protein complex binding protein homodimerization activity transcription regulatory region DNA binding intronic transcription regulatory region DNA binding protein heterodimerization activity thyroid hormone binding DNA binding single-stranded RNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding sequence-specific DNA binding protein dimerization activity
Process(es)
cartilage condensation ossification kidney development liver development regulation of thyroid hormone mediated signaling pathway regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter brain development learning or memory regulation of heart contraction female courtship behavior response to cold hormone-mediated signaling pathway organ morphogenesis positive regulation of myotube differentiation negative regulation of RNA polymerase II transcriptional preinitiation complex assembly erythrocyte differentiation lung development adrenal gland development intracellular receptor signaling pathway thyroid gland development response to nutrient levels regulation of myeloid cell apoptotic process response to drug cytoplasmic sequestering of transcription factor steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter digestive tract development embryonic organ development regulation of lipid catabolic process Type I pneumocyte differentiation negative regulation of DNA-templated transcription, initiation transcription initiation from RNA polymerase II promoter
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