OriGene

THRA Monoclonal Antibody (OTI5A8), TrueMAB™

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CF805057

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI5A8

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-220 of human THRA produced in E.coli.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-erbA-1; c-erbA-alpha; cerbA protein; cerbAalpha; E ERB-T-1; EAR-7; ERBA ALPHA; ERBA related 7; ERBA-related 7; MGC000261; MGC43240; Nuclear receptor subfamily 1 group A member 1; Oncogene ERBA; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; TR; TR alpha 1+2; triiodothyronine receptor; V-erbA-related protein 7

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Gene Aliases: AR7; c-ERBA-1; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; THRA; THRA1; THRA2

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UniProt ID: (Human) P10827

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Entrez Gene ID: (Human) 7067

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Function(s)
transcription regulatory region sequence-specific DNA binding steroid receptor RNA activator RNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity thyroid hormone receptor activity protein binding transcription factor binding zinc ion binding TBP-class protein binding protein domain specific binding chromatin DNA binding protein complex binding protein homodimerization activity transcription regulatory region DNA binding intronic transcription regulatory region DNA binding protein heterodimerization activity thyroid hormone binding
Process(es)
cartilage condensation ossification kidney development liver development regulation of thyroid hormone mediated signaling pathway regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter brain development learning or memory regulation of heart contraction female courtship behavior response to cold hormone-mediated signaling pathway positive regulation of myotube differentiation negative regulation of RNA polymerase II transcriptional preinitiation complex assembly erythrocyte differentiation adrenal gland development intracellular receptor signaling pathway thyroid gland development response to nutrient levels regulation of myeloid cell apoptotic process response to drug cytoplasmic sequestering of transcription factor steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter digestive tract development embryonic organ development regulation of lipid catabolic process Type I pneumocyte differentiation negative regulation of DNA-templated transcription, initiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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