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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • THRB Antibodies

          Invitrogen

          THRB Polyclonal Antibody

          2 Published Figures
          12 References
          View all (8) THRB antibodies

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          Datasheet
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          Datasheet
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          Cite THRB Polyclonal Antibody

          • Antibody Testing Data (6)
          • Published Figures (2)
          THRB Antibody in Immunocytochemistry (ICC/IF)
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          THRB Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 8

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          THRB Antibody (PA1-213A) in ICC/IF

          Immunofluorescent analysis of Thyroid Hormone Receptor beta-1 (green) showing staining in the cytoplasm and nucleus of Hela cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a Thyroid Hormone Receptor beta-1 polyclonal antibody (Product # PA1-213A) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4°C in a humidified chamber. C... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          THRB Antibody in Immunocytochemistry (ICC/IF)
          THRB Antibody in Immunocytochemistry (ICC/IF)
          THRB Antibody in Immunocytochemistry (ICC/IF)
          THRB Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          THRB Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          THRB Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          THRB Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          THRB Antibody in Immunomicroscopy (IM)

          Product Details

          PA1-213A

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:100
          View 3 publications 3 publications

          Immunohistochemistry (IHC)

          -
          View 1 publication 1 publication

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          1:50-1:500
          View 3 publications 3 publications

          ChIP assay (ChIP)

          -
          View 3 publications 3 publications

          Immunomicroscopy (IM)

          -
          View 1 publication 1 publication

          Gel Shift (GS)

          Assay-dependent
          -
          Product Specifications

          Species Reactivity

          Human, Rat

          Published species

          Human, Mouse, Rabbit

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide corresponding to residues C-I(62) F H L D H D D V N D Q S V S S A Q T F(81) of human TR beta-1, with an N-terminal added cysteine.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          Conc. Not Determined

          Storage buffer

          whole serum, PBS

          Contains

          0.05% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2203030

          Product Specific Information

          PA1-213A detects thyroid hormone receptor (TR) beta-1 from human and rat tissues. This antibody does not detect TR alpha-1 or TRv alpha-2.

          PA1-213A has been successfully used in Western blot, immunohistochemistry (paraffin), IF and gel shift procedures. By Western blot, this antibody detects a ~55 kDa protein representing recombinant human TRv beta-1 expressed in E. coli.

          PA1-213A immunizing peptide corresponds to residues 62-81 of human TR beta-1, with an N-terminal added cysteine. Alternative numbering of this protein has this peptide corresponding to residues 67-86 of human TR beta-1. This sequence is completely conserved between human and rat TR beta-1.

          Target Information

          Thyroid hormone receptors (TR), also known as c-erbA-2, are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences called hormone response elements following activation by the appropriate hormone. Thyroid hormones, through their interaction with TR, effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins. There are two forms of TR; TR alpha (on chromosome 17) and TR beta (on chromosome 3). Each of these isoforms also has two isoforms; TR alpha-1 and TRv alpha-2, and TR beta-1 and TR beta-2 respectively. TR alpha-1 and 2 are identical through amino acid 370 where their sequences diverge. TRv alpha-2, which does not bind T3 and is a strong negative regulator of the functional TR, is 80 amino acids longer than TR alpha-1. The corresponding gene for the thyroid hormone receptor beta-1 is NR1A2.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: c-erbA-2; c-erbA-beta; ERBA 2; ERBA BETA; ERBA-BETA; MGC126109; MGC126110; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; thyroid hormone nuclear receptor beta variant 1; Thyroid hormone receptor beta; thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); TR; TR beta 1; TR-B1C-ERBA-2; TRbeta2Delta

          View more View less

          Gene Aliases: C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2; PRTH; RATT3REC; T3rec; THR1; THRB; THRB1; THRB2; TRbeta

          View more View less

          UniProt ID: (Human) P10828

          View more View less

          Entrez Gene ID: (Human) 7068, (Rat) 24831

          View more View less

          Function(s)
          DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription corepressor activity thyroid hormone receptor activity protein binding zinc ion binding enzyme binding chromatin DNA binding sequence-specific DNA binding thyroid hormone binding double-stranded DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein homodimerization activity
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated transcription initiation from RNA polymerase II promoter sensory perception of sound negative regulation of female receptivity regulation of heart contraction female courtship behavior organ morphogenesis intracellular receptor signaling pathway steroid hormone mediated signaling pathway positive regulation of transcription from RNA polymerase II promoter Type I pneumocyte differentiation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of cell proliferation regulation of lipid metabolic process positive regulation of chondrocyte differentiation positive regulation of ossification negative regulation of transcription, DNA-templated embryonic organ development regulation of cholesterol metabolic process regulation of triglyceride metabolic process
          It has to be done as per old AB suggested Products section.
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