Proteintech

THRSP Polyclonal Antibody

THRSP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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THRSP Antibody (13054-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver tissue slide using (Product # 13054-1-AP) (THRSP antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

THRSP Antibody in Immunoprecipitation (IP)

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Product Details

13054-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:600

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

THRSP Fusion Protein Ag3721 (1-146 aa encoded by BC031989)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody works well in IHC, WB and IF.

Immunogen sequence: MQVLTKRYP KNCLLTVMDR YAAEVHNMEQ VVMIPSLLRD VQLSGPGGQA QAEAPDLYTY FTMLKAICVD VDHGLLPREE WQAKVAGSEE NGTAETEEVE DESASGELDL EAQFHLHFSS LHHILMHLTE KAQEVTRKYQ EMTGQVW (1-146 aa encoded by BC031989)

Target Information

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes.

Molecular medicine (Cambridge, Mass.)

Ahonen MA,Höring M,Nguyen VD,Qadri S,Taskinen JH,Nagaraj M,Wabitsch M,Fischer-Posovszky P,Zhou Y,Liebisch G,Haridas PAN,Yki-Järvinen H,Olkkonen VM

Fri Jun 17 00:00:00 UTC 2022

Elevated serum S14 levels are associated with more severe liver steatosis by ultrasonography.

Scientific reports

Lin WT,Yang KC,Chen YT,Huang KC,Yang WS

Fri Dec 17 00:00:00 UTC 2021

The serum level of a novel lipogenic protein Spot 14 was reduced in metabolic syndrome.

PloS one

Chen YT,Tseng PH,Tseng FY,Chi YC,Han DS,Yang WS

Wed Nov 20 00:00:00 UTC 2019

MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene.

Molecular and cellular endocrinology

Zeng N,Huang R,Li N,Jiang H,Li R,Wang F,Chen W,Xia M,Wang Q

Mon Oct 15 00:00:00 UTC 2018

MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene.

Molecular and cellular endocrinology

Zeng N,Huang R,Li N,Jiang H,Li R,Wang F,Chen W,Xia M,Wang Q

Mon Oct 15 00:00:00 UTC 2018

Serum Spot 14 concentration is negatively associated with thyroid-stimulating hormone level.

Medicine

Chen YT,Tseng FY,Chen PL,Chi YC,Han DS,Yang WS

Sat Oct 01 00:00:00 UTC 2016

Serum Spot 14 concentration is negatively associated with thyroid-stimulating hormone level.

Medicine

Chen YT,Tseng FY,Chen PL,Chi YC,Han DS,Yang WS

Sat Oct 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: lipogenic protein 1; Lipogenic protein S14; S14; S14MGC21659; Spot 14 protein; SPOT14; SPOT14 homolog; thyroid hormone responsive (SPOT14 homolog, rat); thyroid hormone responsive SPOT14; thyroid hormone responsive SPOT14 homolog; Thyroid hormone-inducible hepatic protein

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Gene Aliases: Lpgp; LPGP1; S14; SPOT14; THRP; THRSP

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UniProt ID: (Human) Q92748, (Mouse) Q62264

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Entrez Gene ID: (Human) 7069, (Mouse) 21835, (Rat) 25357

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Function(s)

protein homodimerization activity protein binding

Process(es)

transcription, DNA-templated regulation of transcription, DNA-templated lipid metabolic process regulation of triglyceride biosynthetic process regulation of lipid biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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THRSP Polyclonal Antibody

THRSP Antibody (13054-1-AP) in IHC (P)

Product Details

13054-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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