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TIAM 1 Polyclonal Antibody
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Product Details
OST00086G-500UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from human T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1, TIAM1) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TIAM1.
Target Information
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: human T-lymphoma invasion and metastasis inducing TIAM1 protein; Rho guanine nucleotide exchange factor TIAM1; T-cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1; TIAM-1
Gene Aliases: AI847750; D16Ium10; D16Ium10e; TIAM1
UniProt ID: (Human) Q13009
Entrez Gene ID: (Human) 7074, (Mouse) 21844
receptor signaling protein activity
guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
protein binding
microtubule binding
lipid binding
kinase binding
Rac guanyl-nucleotide exchange factor activity
receptor tyrosine kinase binding
Rac GTPase binding
phospholipid binding
ephrin receptor binding
cardiac muscle hypertrophy
apoptotic process
cell-matrix adhesion
cell migration
Rac protein signal transduction
positive regulation of protein binding
regulation of Rho protein signal transduction
response to cocaine
positive regulation of apoptotic process
positive regulation of JUN kinase activity
ephrin receptor signaling pathway
positive regulation of axonogenesis
regulation of small GTPase mediated signal transduction
Wnt signaling pathway, planar cell polarity pathway
positive regulation of dendritic spine morphogenesis
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of ERK1 and ERK2 cascade
protein localization to membrane
activation of GTPase activity
positive regulation of Schwann cell chemotaxis
regulation of dopaminergic neuron differentiation
neuron projection extension
regulation of non-canonical Wnt signaling pathway
signal transduction
small GTPase mediated signal transduction
positive regulation of neuron projection development
brain-derived neurotrophic factor receptor signaling pathway
intracellular signal transduction
regulation of GTPase activity
positive regulation of GTPase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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